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Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability

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Abstract

This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters. Sixteen adults with ASD (ASD-Only), 12 adults with ASD medicated for comorbid diagnoses of anxiety and/or depression (ASD-Med) and 32 controls participated in the study. Although, the timing of the DLMO did not differ between the two groups, advances and delays of the melatonin rhythm were observed in individual profiles. Overall mean melatonin levels were lower in the ASD-Med group compared to the two other groups. Lastly, greater increases in melatonin in the hour prior to sleep were associated with greater sleep efficiency in the ASD groups.

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References

  • American Academy of Sleep Medicine (2014). International Classification of Sleep Disorders (3rd edn.). Darien, IL: American Academy of Sleep Medicine.

    Google Scholar 

  • Antonioli, M., Rybka, J., & Carvalho, L. A. (2012). Neuroimmune endocrine effects of antidepressants. Neuropsychiatric Disease and Treatment, 8, 65–83. doi:10.2147/NDT.S16409.

    PubMed  PubMed Central  Google Scholar 

  • Arendt, J. (1995). Melatonin and the mammalian pineal gland (1st ed.). London: Chapman & Hall.

    Google Scholar 

  • Baker, E. K., & Richdale, A. L. (2015). Sleep patterns in adults with a diagnosis of high-functioning autism spectrum disorder. Sleep, 38(11), 1765–1774. doi:10.5665/sleep.5160.

    Article  PubMed  PubMed Central  Google Scholar 

  • Baker, E. K., & Richdale, A. L. (2017). Examining the behavioural sleep–wake rhythm in adults with autism spectrum disorder and no comorbid intellectual disability. Journal of Autism and Developmental Disorders, 47, 1207–1222. doi:10.1007/s10803-017-3042-3.

    Article  PubMed  Google Scholar 

  • Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from asperger syndrome/high-functioning autism, malesand females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. doi:10.1023/a:1005653411471.

    Article  PubMed  Google Scholar 

  • Benloucif, S., Burgess, H. J., Klerman, E. B., Lewy, A. J., Middleton, B., Murphy, P. J., … Revell, V. L. (2008). Measuring melatonin in humans. Journal of Clinical Sleep Medicine, 4, 66–69.

    PubMed  PubMed Central  Google Scholar 

  • Benowitz, N. L. (1990). Clinical pharmacology of caffeine. Annual Review of Medicine, 41, 277–288. doi:10.1146/annurev.me.41.020190.001425.

    Article  PubMed  Google Scholar 

  • Bootzin, R., Shoham, V., & Kuo, T. (1994). Sleep anticipatory anxiety questionnaire: A measure of anxiety about sleep. Sleep Research, 23, 188.

    Google Scholar 

  • Brzezinski, A. (1997). Melatonin in humans. The New England Journal of Medicine, 336(3), 186–195. doi:10.1056/NEJM199701163360306.

    Article  PubMed  Google Scholar 

  • Burgess, H. J., & Eastman, C. I. (2005). The dim light melatonin onset following fixed and free sleep schedules. Journal of Sleep Research, 14(3), 229–237. doi:10.1111/j.1365-2869.2005.00470.x.

    Article  PubMed  Google Scholar 

  • Burgess, H. J., Wyatt, J. K., Park, M., & Fogg, L. F. (2015). Home circadian phase assessments with measures of compliance yield accurate dim light melatonin onsets. Sleep, 38(6), 889–897. doi:10.5665/sleep.4734.

    PubMed  PubMed Central  Google Scholar 

  • Carvalho, L. A., Gorenstein, C., Moreno, R., Pariante, C., & Markus, R. P. (2009). Effect of antidepressants on melatonin metabolite in depressed patients. Journal of Psychopharmacology, 23(3), 315–321. doi:10.1177/0269881108089871.

    Article  PubMed  Google Scholar 

  • Cohrs, S., Pohlmann, K., Guan, Z., Jordan, W., Meier, A., Huether, G., Rüther, E., & Rodenbeck, A. (2004). Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects. Psychopharmacology, 174, 414–420, doi:10.1007/s00213-003-1766-6.

    PubMed  Google Scholar 

  • Cortesi, F., Giannotti, F., Sebastiani, T., Panunzi, S., & Valente, D. (2012). Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. Journal of Sleep Research, 21(6), 700–709, doi:10.1111/j.1365-2869.2012.01021.x.

    Article  PubMed  Google Scholar 

  • Crasson, M., Kjiri, S., Colin, A., Kjiri, K., L’Hermite-Baleriaux, M., Ansseau, M., et al. (2004). Serum melatonin and urinary 6-sulfatoxymelatonin in major depression. Psychoneuroendocrinology, 29(1), 1–12. [doi:10.1016/S0306-4530(02)00123-3].

    Article  PubMed  Google Scholar 

  • Crowley, S. J. (2013). Assessment of Circadian Rhythms. In A. Wolfson & H. Montgomery-Downs (Eds.), The Oxford Handbook of Infant, Child, and Adolescent Sleep and Behavior. New York, NY: Oxford University Press.

    Google Scholar 

  • Darcourt, G., Feuillade, P., Bistagnin, Y., Robert, P., Pringuey, D., Touari, M., Mrdji, Y., & Bensmaïl, B. (1995). Antidepressant effect of 5-methoxypsoralen: The melatonin synchronizer hypothesis. European Psychiatry, 10(3), 142–154. doi:10.1016/0767-399X(96)80103-9.

    Article  PubMed  Google Scholar 

  • Dijk, D. J., & Cajochen, C. (1997). Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. Journal of Biological Rhythms, 12(6), 627–635.

    Article  PubMed  Google Scholar 

  • Elrod, M. G., & Hood, B. S. (2015). Sleep differences among children with autism spectrum disorders and typically developing peers: A meta-analysis. Journal of Developmental and Behavioral Pediatrics, 36(3), 166–177.

    Article  PubMed  Google Scholar 

  • Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009). Circadian misalignment in major depressive disorder. Psychiatry Research, 168(3), 259–261. doi:10.1016/j.psychres.2009.04.009.

    Article  PubMed  Google Scholar 

  • Franklin, M., Clement, E. M., Campling, G., & Cowen, P. J. (1998). Effect of venlafaxine on pineal melatonin and noradrenaline in the male rat. Journal of Psychopharmacology, 12(4), 371–374.

    Article  PubMed  Google Scholar 

  • Glickman, G. (2010). Circadian rhythms and sleep in children with autism. Neuroscience and Biobehavioral Reviews, 34(5), 755–768. doi:10.1016/j.neubiorev.2009.11.017.

    Article  PubMed  Google Scholar 

  • Goldman, S. E., Adkins, K. W., Calcutt, M. W., Carter, M. D., Goodpaster, R. L., Wang, L., et al. (2014). Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep. Journal of Autism and Developmental Disorders, 44(10), 2525–2535. doi:10.1007/s10803-014-2123-9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldman, S. E., Surdyka, K., Cuevas, R., Adkins, K., Wang, L., & Malow, B. (2009). Defining the sleep phenotype in children with autism. Developmental Neuropsychology, 34(5), 560–573. doi:10.1080/87565640903133509.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gotham, K., Brunwasser, S. M., & Lord, C. (2015). Depressive and anxiety symptom trajectories from school age through young adulthood in samples with autism spectrum disorder and developmental delay. Journal of the American Academy of Child & Adolescent Psychiatry, 54(5), 369–376.e363. doi:10.1016/j.jaac.2015.02.005.

    Article  Google Scholar 

  • Gringras, P., Gamble, C., Jones, A. P., Wiggs, L., Williamson, P. R., Sutcliffe, A., et al. (2012). Melatonin for sleep problems in children with neurodevelopmental disorders: Randomised double masked placebo controlled trial. BMJ (Clinical research ed.), 345, e6664. doi:10.1136/bmj.e6664.

    PubMed Central  Google Scholar 

  • Guénolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J.-M. (2011). Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion. Sleep Medicine Reviews, 15(6), 379–387.

    Article  PubMed  Google Scholar 

  • Hallam, K. T., Begg, D. P., Olver, J. S., & Norman, T. R. (2008). An investigation of the effect of immediate and extended release venlafaxine on nocturnal melatonin and cortisol release in healthy adult volunteers. Human Psychopharmacology: Clinical and Experimental, 23(2), 129–137. doi:10.1002/hup.913.

    Article  Google Scholar 

  • Hare, D. J., Jones, S., & Evershed, K. (2006). A comparative study of circadian rhythm functioning and sleep in people with Asperger syndrome. Autism: The International Journal of Research and Practice, 10(6), 565–575. doi:10.1177/1362361306068509.

    Article  Google Scholar 

  • Hariharasubramanian, N., Nair, N. P., Pilapil, C., Isaac, I., & Quirion, R. (1986). Effect of imipramine on the circadian rhythm of plasma melatonin in unipolar depression. Chronobiology International, 3(1), 65–69.

    Article  PubMed  Google Scholar 

  • Härtter, S., Want, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F., & Hiemke, C. (2001). Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. Journal of Clinical Psychopharmacology, 21(2), 167–174.

    Article  PubMed  Google Scholar 

  • Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010). Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: Further evidence for circadian misalignment in non-seasonal depression. Psychiatry Research, 178(1), 205–207. doi:10.1016/j.psychres.2010.04.027.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hilli, J., Korhonen, T., Turpeinen, M., Hokkanen, J., Mattila, S., & Laine, K. (2008). The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C > A polymorphism. Journal of Clinical Pharmacology, 48(8), 986–994. doi:10.1177/0091270008318669.

    Article  PubMed  Google Scholar 

  • Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325. doi:10.1007/s10803-012-1679-5.

    Article  PubMed  Google Scholar 

  • Keijzer, H., Smits, M. G., Duffy, J. F., & Curfs, L. M. (2014). Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep Medicine Reviews, 18(4), 333–339. doi:10.1016/j.smrv.2013.12.001.

    Article  PubMed  Google Scholar 

  • Kroenke, K., Strine, T. W., Spitzer, R. L., Williams, J. B. W., Berry, J. T., & Mokdad, A. H. (2009). The PHQ-8 as a measure of current depression in the general population. Journal of Affective Disorders, 114(1–3), 163–173. doi:10.1016/j.jad.2008.06.026.

    Article  PubMed  Google Scholar 

  • Kulman, G., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., & Sequeri, P. (2000). Evidence of pineal endocrine hypofunction in autistic children. Neuro Endocrinology Letters, 21(1), 31–34.

    PubMed  Google Scholar 

  • Li, S., Liu, L., Xu, L., Gao, L., Wang, X., Zhang, J., & Lu, L. (2013). Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment. Psychoneuroendocrinology, 38, 2789–2899, doi:10.1016/j.psyneuen.2013.07.009.

    Article  PubMed  Google Scholar 

  • Leu, R. M., Beyderman, L., Botzolakis, E. J., Surdyka, K., Wang, L., & Malow, B. A. (2011). Relation of melatonin to sleep architecture in children with autism. [Research Support, Non-U.S. Gov’t]. Journal of Autism and Developmental Disorders, 41(4), 427–433, doi:10.1007/s10803-010-1072-1.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism Diagnostic Observation Schedule (2nd edn.). Los Angeles, CA: Western Psychological Services.

    Google Scholar 

  • Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., et al. (2012). Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. Journal of Autism and Developmental Disorders, 42(8), 1729–1737. doi:10.1007/s10803-011-1418-3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsater, H., et al. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13(1), 90–98. doi:10.1038/sj.mp.4002016.

    Article  PubMed  Google Scholar 

  • Morin, L. P., & Allen, C. N. (2006). The circadian visual system, 2005. Brain Research Reviews, 51(1), 1–60. doi:10.1016/j.brainresrev.2005.08.003.

    Article  PubMed  Google Scholar 

  • Nadeau, J. M., Arnold, E. B., Keene, A. C., Collier, A. B., Lewin, A. B., Murphy, T. K., & Storch, E. A. (2015). Frequency and clinical correlates of sleep-related problems among anxious youth with autism sepctrum disorders. Child Psychiatry and Human Development, 46, 558–566. doi:10.1007/s10578-014-0496-9.

    Article  PubMed  Google Scholar 

  • Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995). Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. Journal of Autism and Developmental Disorders, 25(6), 641–654.

    Article  PubMed  Google Scholar 

  • Pagan, C., Delorme, R., Callebert, J., Goubran-Botros, H., Amsellem, F., Drouot, X., et al. (2014). The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational Psychiatry, 4, e479. doi:10.1038/tp.2014.120.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pandi-Perumal, S. R., Smits, M., Spence, W., Srinivasan, V., Cardinali, D. P., Lowe, A. D., et al. (2007a). Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, 31(1), 1–11. doi:10.1016/j.pnpbp.2006.06.020.

    Article  Google Scholar 

  • Pandi-Perumal, S. R., Srinivasan, V., Maestroni, G. J., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006). Melatonin: Nature’s most versatile biological signal? FEBS J, 273(13), 2813–2838, doi:10.1111/j.1742-4658.2006.05322.x.

    Article  PubMed  Google Scholar 

  • Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., & Cardinali, D. P. (2007b). Role of the melatonin system in the control of sleep: Therapeutic implications. CNS Drugs, 21(12), 995–1018.

    Article  PubMed  Google Scholar 

  • Papp, M., Litwa, E., Gruca, P., & Mocaer, E. (2006). Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behavioural Pharmacology, 17(1), 9–18.

    PubMed  Google Scholar 

  • Patzold, L. M., Richdale, A. L., & Tonge, B. J. (1998). An investigation into sleep characteristics of children with autism and Asperger’s disorder. Journal of Paediatrics and Child Health, 34, 528–533.

    Article  PubMed  Google Scholar 

  • Richdale, A. L. (1999). Sleep problems in autism: Prevalence, cause, and intervention. Developmental Medicine and Child Neurology, 41, 60–66.

    Article  PubMed  Google Scholar 

  • Richdale, A. L., & Schreck, K. A. (2009). Sleep problems in autism spectrum disorders: Prevalence, nature & possible biopsychosocial aetiologies. Sleep Medicine Reviews, 13(6), 403–411.

    Article  PubMed  Google Scholar 

  • Ritvo, E., Ritvo, R., Yuwiler, A., Brothers, A., Freeman, B., & Plotkin, S. (1993). Elevated daytime melatonin concentrations in autism: A pilot study. European Child & Adolescent Psychiatry, 2(2), 75–78. doi:10.1007/bf02098862.

    Article  Google Scholar 

  • Robillard, R., Naismith, S. L., Rogers, N. L., Scott, E. M., Ip, T. K., Hermens, D. F., et al. (2013). Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. European Psychiatry, 28(7), 412–416. doi:10.1016/j.eurpsy.2013.04.001.

    Article  PubMed  Google Scholar 

  • Rubin, R. T., Heist, E., McGeoy, S. S., Hanada, K., & Lesser, I. (1992). Neuroendocrine aspects of primary endogenous depression: Xi. serum melatonin measures in patients and matched control subjects. Archives of General Psychiatry, 49(7), 558–567. doi:10.1001/archpsyc.1992.01820070052008.

    Article  PubMed  Google Scholar 

  • Salti, R., Galluzzi, F., Bindi, G., Perfetto, F., Tarquini, R., Halberg, F., et al. (2000). Nocturnal melatonin patterns in children. Journal of Clinical Endocrinology and Metabolism, 85, 2137–2144.

    Article  PubMed  Google Scholar 

  • Spielberger, C. D., Gorsuch, R. L., Lushene, R., Vagg, P. R., & Jacobs, G. A. (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.

    Google Scholar 

  • Tordjman, S., Anderson, G. M., Bellissant, E., Botbol, M., Charbuy, H., Camus, F., … Touitou, Y. (2012). Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder. Psychoneuroendocrinology, 37, 1990–1997. doi:10.1016/j.psyneuen.2012.04.013.

    Article  PubMed  Google Scholar 

  • Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., & Touitou, Y. (2005). Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry, 57(2), 134–138. doi:10.1016/j.biopsych.2004.11.003.

    Article  PubMed  Google Scholar 

  • Tsaousis, I. (2010). Circadian preferences and personality traits: A meta-analysis. European Journal of Personality, 24(4), 356–373. doi:10.1002/per.754.

    Google Scholar 

  • von Bahr, C., Ursing, C., Yasui, N., Tybring, G., Bertilsson, L., & Röjdmark, S. (2000). Fluvoxamine but not citalopram increases serum melatonin in healthy subjects—an indication that cytochrome P 450 CYP1A2 and CYP2C19 hydroxylate melatonin. European Journal of Clinical Pharmacology, 56(2), 123–127. doi:10.1007/s002280050729.

    Article  Google Scholar 

  • Voultsios, A., Kennaway, D. J., & Dawson, D. (1997). Salivary melatonin as a circadian phase marker: Validation and comparison to plasma melatonin. Journal of Biological Rhythms, 12(5), 457–466.

    Article  PubMed  Google Scholar 

  • Wasdell, M. B., Jan, J. E., Bomben, M. M., Freeman, R. D., Rietveld, W. J., Tai, J., et al. (2008). A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. Journal of Pineal Research, 44, 57–64. doi:10.1111/j.1600-079X.2007.00528.x.

    PubMed  Google Scholar 

  • Wechsler, D. (1999). WASI Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Wechsler, D. (2008). WAIS-IV Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Wiggs, L., & Stores, G. (2004). Sleep patterns and sleep disorders in children with autistic spectrum disorders: Insights using parent report and actigraphy. Developmental Medicine & Child Neurology, 46(6), 372–380. doi:10.1017/S0012162204000611.

  • Woodbury-Smith, M. R., Robinson, J., Wheelwright, S., & Baron-Cohen, S. (2005). Screening adults for Asperger Syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. Journal of Autism and Developmental Disorders, 35(3), 331–335.

    Article  PubMed  Google Scholar 

  • Zawilska, J. B., Skene, D. J., & Arendt, J. (2009). Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacological Reports, 61(3), 383–410.

    Article  PubMed  Google Scholar 

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Acknowledgments

We would like to thank all the participants for their time on this project.

Author Contributions

EKB participated in the design of the study, conducted analyses, interpreted analyses and drafted the manuscript. ALR and AH participated in the design of the study, advised on the interpretation of data and reviewed the manuscript. LAP conducted analyses, advised on the interpretation of data and reviewed the manuscript. All authors read and approved the final manuscript.

Funding

This study was partially supported by a Ph.D. Grant awarded to the first author from the APEX Trust for Autism.

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Authors and Affiliations

  1. School of Psychology and Public Health, Olga Tennison Autism Research Centre, La Trobe University, Kingsbury Drive, Bundoora, VIC, 3086, Australia

    Emma K. Baker & Amanda L. Richdale

  2. School of Psychology and Public Health, La Trobe University, Bundoora, VIC, 3086, Australia

    Emma K. Baker, Amanda L. Richdale & Agnes Hazi

  3. School of Mathematics and Statistics, La Trobe University, Bundoora, VIC, 3086, Australia

    Luke A. Prendergast

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  1. Emma K. Baker
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Correspondence to Amanda L. Richdale.

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Baker, E.K., Richdale, A.L., Hazi, A. et al. Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability. J Autism Dev Disord 47, 2120–2137 (2017). https://doi.org/10.1007/s10803-017-3122-4

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