Abstract
The objective of this study is to evaluate local response to a bioactive glass based composite putty (NovaBone Putty) in a vertebral body defect model in sheep, as compared to NovaBone, a bioactive glass particulate. Two time periods were used for the study, 6 and 12 weeks. Empty defects were also used as a control. In comparing the three test groups, the relative amount of new bone for both grafted defects was substantially greater than for the empty controls (P < 0.05). At 6 weeks, the bone formation was 42% for NovaBone Putty, 27% for NovaBone and 1.2% for the ungrafted empty defect. At 12 weeks, the bone formation was 51.4% for NovaBone Putty, 47.3% for NovaBone and 5.1% for the empty defect. NovaBone Putty, the test material, had greater bone content than the NovaBone, both of which were significantly greater than the empty control.
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Acknowledgments
This study was supported by research funds from NovaBone Products, LLC and from the Musculoskeletal Transplant Foundation, and the funds of the Chinese Academy of Sciences for Key Topics in Innovation Engineering (Grant No.: KGCX2-YW-207).
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Wang, Z., Lu, B., Chen, L. et al. Evaluation of an osteostimulative putty in the sheep spine. J Mater Sci: Mater Med 22, 185–191 (2011). https://doi.org/10.1007/s10856-010-4175-5
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DOI: https://doi.org/10.1007/s10856-010-4175-5