Abstract
One of the most aggressive cancers is hepatocellular carcinoma, which is associated with a very poor patient outcome due to a high recurrence rate and metastatic spread. NM23, the first metastasis suppressor gene to be identified, has been widely studied in human cancers. However, conflicting results have been obtained depending on the tumor type and the evaluation protocol. The current knowledge of NM23 as a diagnostic and/or prognostic marker in hepatocellular carcinoma is reviewed herein. Most studies demonstrate an inverse association between the expression of NM23-H1 and the metastatic potential, which is not observed with the closely related NM23-H2 isoform. Transfection of metastatic hepatoma cells with NM23 reduced their metastatic potential, as for other tumor cell lines. The demonstration of a causative role of NM23 in metastatic dissemination in a mouse model of hepatocarcinoma suggests that hepatocarcinoma-derived cells could be good models for the analysis of the molecular mechanisms involved in NM23 action.
Similar content being viewed by others
References
Arnaud-Dabernat S, Bourbon PM, Dierich A, Le Meur M, Daniel JY (2003) J Bioenerg Biomembr 35:19–30
Bertucci F, Salas S, Eysteries S, Nasser V, Finetti P, Ginestier C, Charafe-Jauffret E, Loriod B, Bachelart L, Montfort J, Victorero G, Viret F, Ollendorff V, Fert V, Giovaninni M, Delpero JR, Nguyen C, Viens P, Monges G, Birnbaum D, Houlgatte R (2004) Oncogene 23:1377–1391
Boissan M, Beurel E, Wendum D, Rey C, Lecluse Y, Housset C, Lacombe ML, Desbois-Mouthon C (2005a) Am J Pathol 167:869–877
Boissan M, Wendum D, Arnaud-Dabernat S, Munier A, Debray M, Lascu I, Daniel JY, Lacombe ML (2005b) J Natl Cancer Inst 97:836–845
Boix L, Bruix J, Campo E, Sole M, Castells A, Fuster J, Rivera F, Cardesa A, Rodes J (1994) Gastroenterology 107:486–491
Buendia MA (2002) Med Pediat Oncol 39:530–535
Chen SL, Wu YS, Shieh HY, Yen CC, Shen JJ, Lin KH (2003) Mol Carcinog 36:204–214
Cheng S, Alfonso-Jaume MA, Mertens PR, Lovett DH (2002) Biochem J 366:807–816
Cui J, Dong BW, Liang P, Yu XL, Yu DJ (2005) World J Gastroenterol 11:3027–3033
de Otero SA (2000) J Bioenerg Biomembr 32:269–275
Delpuech O, Trabut JB, Carnot F, Feuillard J, Brechot C, Kremsdorf D (2002) Oncogene 21:2926–2937
Ding SJ, Li Y, Shao XX, Zhou H, Zeng R, Tang ZY, Xia QC (2004) Proteomics 4:982–994
Duan LL, Guo P, Zhang Y, Chen HL (2005) J Cell Biochem 94:1248–1257
El-Serag HB (2004) Gastroenterology 127:S27–S34
Fournier HN, Albiges-Rizo C, Block MR (2003) J Bioenerg Biomembr 35:81–87
Fujimoto Y, Ohtake T, Nishimori H, Ikuta K, Ohhira M, Ono M, Kohgo Y (1998) J Gastroenterol 33:368–375
Guo HB, Liu F, Zhao JH, Chen HL (2000) J Cell Biochem 79:370–385
Guo XZ, Friess H, Di Mola FF, Heinicke JM, Abou-Shady M, Graber HU, Baer HU, Zimmermann A, Korc M, Buchler MW (1998) Hepatology 28:1481–1488
Hartsough MT, Steeg PS (2000) J Bioenerg Biomembr 32:301–308
Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M, Patrick J, Steeg PS (2002) J Biol Chem 277:32389–32399
Huang B, Wu ZB, Ruan YB (1998) World J Gastroenterol 4:266–267
Huang CS, Shih MK, Chuang CH, Hu ML (2005) J Nutr 135:2119–2123
Iizuka N, Mori N, Tamesa T, Tangoku A, Oka M (2003) Anticancer Res 23:43–47
Iizuka N, Oka M, Noma T, Nakazawa A, Hirose K, Suzuki T (1995) Cancer Res 55:652–657
Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H (2003) Cancer Res 63:8763–8767
Jiang XP, Tang ZY, Liu KD, Zhou XD, Lin ZY, Ling MY, Wu XF (1996) J Cancer Res Clin Oncol 122:55–58
Kimura N, Shimada N, Ishijima Y, Fukuda M, Takagi Y, Ishikawa N (2003) J Bioenerg Biomembr 35:41–47
Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO (2000) J Bioenerg Biomembr 32:247–258
Lacombe ML, Sastre-Garau X, Lascu I, Vonica A, Wallet V, Thiery JP, Veron M (1991) Eur J Cancer 27:1302–1307
Le Naour F, Brichory F, Misek DE, Brechot C, Hanash SM, Beretta L (2002) Mol Cell Proteomics 1:197–203
Lee JS, Grisham JW, Thorgeirsson SS (2005) Carcinogenesis 26:1013–1020
Leone A, Flatow U, King CR, Sandeen MA, Margulies IM, Liotta LA, Steeg PS (1991) Cell 65:25–35
Li Y, Tang Z, Ye S, Liu Y, Chen J, Xue Q, Huang X, Bao W, Yang J, Gao D (2002) Zhonghua Yi Xue Za Zhi 82:601–605
Lin KH, Lin YW, Lee HF, Liu WL, Chen ST, Chang KS, Cheng SY (1995) Cancer Lett 98:89–95
Lin KH, Shieh HY, Hsu HC (2000) Endocrinology 141:2540–2547
Lin LI, Lee PH, Wu CM, Lin JK (1998) Anticancer Res 18:541–546
Liu F, Qi HL, Chen HL (2000) J Cancer Res Clin Oncol 126:85–90
Liu F, Zhang Y, Zhang XY, Chen HL (2002) J Cancer Res Clin Oncol 128:189–196
Liu YB, Gao SL, Chen XP, Peng SY, Fang HQ, Wu YL, Peng CH, Tang Z, Xu B, Wang JW, Deng GL, Li HJ, Feng XD, Qian HR (2005) World J Gastroenterol 11:1378–1381
Ma D, Xing Z, Liu B, Pedigo N, Zimmer S, Bai Z, Postel E, Kaetzel D (2002) J Biol Chem 277:1560–1567
Martinez JA, Prevot S, Nordlinger B, Nguyen TM, Lacarriere Y, Munier A, Lascu I, Vaillant JC, Capeau J, Lacombe ML (1995) Gut 37:712–720
Nakayama T, Ohtsuru A, Nakao K, Shima M, Nakata K, Watanabe K, Ishii N, Kimura N, Nagataki S (1992) J Natl Cancer Inst 84:1349–1354
Nanashima A, Yano H, Yamaguchi H, Tanaka K, Shibasaki S, Sumida Y, Sawai T, Shindou H, Nakagoe T (2004) J Gastroenterol 39:148–154
Narayanan R, Ramaswami M (2003) J Bioenerg Biomembr 35:49–55
Otsuki Y, Tanaka M, Yoshii S, Kawazoe N, Nakaya K, Sugimura H (2001) Proc Natl Acad Sci USA 98:4385–4390
Ouatas T, Salerno M, Palmieri D, Steeg PS (2003) J Bioenerg Biomembr 35:73–79
Ozturk M (1999) Semin Liver Dis 19:235–242
Postel EH (2003) J Bioenerg Biomembr 35:31–40
Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993) Science 261:478–480
Sadek CM, Jimenez A, Damdimopoulos AE, Kieselbach T, Nord M, Gustafsson JA, Spyrou G, Davis EC, Oko R, van der Hoorn FA, Miranda-Vizuete A (2003) J Biol Chem 278:13133–13142
Salerno M, Palmieri D, Bouadis A, Halverson D, Steeg PS (2005) Mol Cell Biol 25:1379–1388
Scharf JG, Braulke T (2003) Horm Metab Res 35:685–693
Seki S, Kitada T, Kawada N, Sakaguchi H, Kadoya H, Nakatani K, Satake K, Kuroki T (1999) Hepatogastroenterology 46:2812–2817
Shevde LA, Welch DR (2003) Cancer Lett 198:1–20
Shimada M, Taguchi K, Hasegawa H, Gion T, Shirabe K, Tsuneyoshi M, Sugimachi K (1998) Liver 18:337–342
Shirota Y, Kaneko S, Honda M, Kawai HF, Kobayashi K (2001) Hepatology 33:832–840
Sridhar SC, Miranti CK (2005) Oncogene, in press
Steeg PS (2003) Nat Rev Cancer 3:55–63
Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME (1988) J Natl Cancer Inst 80:200–204
Suzuki E, Ota T, Tsukuda K, Okita A, Matsuoka K, Murakami M, Doihara H, Shimizu N (2004) Int J Cancer 108:207–211
Tang Z, Qin L, Wang X, Zhou G, Liao Y, Weng Y, Jiang X, Lin Z, Liu K, Ye S (1998) Chin Med J (Engl) 111:313–318
Thorgeirsson SS, Grisham JW (2002) Nat Genet 31:339–346
Tian J, Tang ZY, Ye SL, Liu YK, Lin ZY, Chen J, Xue Q (1999) Br J Cancer 81:814–821
Wu X, Jia HL, Wang YF, Ren N, Ye QH, Sun HC, Wang L, Liu YK, Tang ZY, Qin LX (2005) Oncogene, in press
Xiao CZ, Dai YM, Yu HY, Wang JJ, Ni CR (1998) World J Gastroenterol 4:412–414
Xiao EH, Hu GD, Li JQ (2002) Hepatobiliary Pancreat Dis Int 1:574–576
Xiao H, Palhan V, Yang Y, Roeder RG (2000) EMBO J 19:956–963
Yamaguchi A, Urano T, Goi T, Takeuchi K, Niimoto S, Nakagawara G, Furukawa K, Shiku H (1994) Cancer 73:2280–2284
Zheng X, Lin Z, Liu Y (1998) Zhonghua Zhong Liu Za Zhi 20:15–17
Zindy P, Andrieux L, Bonnier D, Musso O, Langouet S, Campion JP, Turlin B, Clement B, Theret N (2005) FEBS Lett {579}:95–99
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Boissan, M., Lacombe, ML. Nm23/NDP kinases in hepatocellular carcinoma. J Bioenerg Biomembr 38, 169–175 (2006). https://doi.org/10.1007/s10863-006-9031-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10863-006-9031-4