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The complex interplay between mitochondrial dynamics and cardiac metabolism

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Abstract

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.

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Authors and Affiliations

  1. Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile

    Valentina Parra, Hugo Verdejo, Andrea del Campo, Christian Pennanen, Jovan Kuzmicic & Sergio Lavandero

  2. Departamento Enfermedades Cardiovasculares, Facultad Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

    Hugo Verdejo

  3. Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA

    Myriam Iglewski, Joseph A. Hill, Beverly A. Rothermel & Sergio Lavandero

  4. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA

    Joseph A. Hill

  5. Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Olivos 1007, Santiago, 8380492, Chile

    Sergio Lavandero

Authors
  1. Valentina Parra
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  2. Hugo Verdejo
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  3. Andrea del Campo
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  4. Christian Pennanen
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  5. Jovan Kuzmicic
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  6. Myriam Iglewski
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  7. Joseph A. Hill
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  8. Beverly A. Rothermel
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  9. Sergio Lavandero
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Corresponding author

Correspondence to Sergio Lavandero.

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Parra, V., Verdejo, H., del Campo, A. et al. The complex interplay between mitochondrial dynamics and cardiac metabolism. J Bioenerg Biomembr 43, 47–51 (2011). https://doi.org/10.1007/s10863-011-9332-0

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  • DOI: https://doi.org/10.1007/s10863-011-9332-0

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