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Lipid peroxidation in brain or spinal cord mitochondria after injury

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Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

Abstract

Extensive evidence has demonstrated an important role of oxygen radical formation (i.e., oxidative stress) as a mediator of the secondary injury process that occurs following primary mechanical injury to the brain or spinal cord. The predominant form of oxygen radical-induced oxidative damage that occurs in injured nervous tissue is lipid peroxidation (LP). Much of the oxidative stress in injured nerve cells initially begins in mitochondria via the generation of the reactive nitrogen species peroxynitrite (PN) which then can generate multiple highly reactive free radicals including nitrogen dioxide (•NO2), hydroxyl radical (•OH) and carbonate radical (•CO3). Each can readily induce LP within the phospholipid membranes of the mitochondrion leading to respiratory dysfunction, calcium buffering impairment, mitochondrial permeability transition and cell death. Validation of the role of LP in central nervous system secondary injury has been provided by the mitochondrial and neuroprotective effects of multiple antioxidant agents which are briefly reviewed.

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Acknowledgments

The research described in the authors’ laboratory was partially funded by grants from the National Institute of Neurological Disorders & Stroke (NINDS) including R01 NS046566, R01 NS083405, R01 NS084857, P01 NS058484, R21 NS077434 and P30 NS051220 and grants from the Kentucky Spinal Cord & Head Injury Research Trust.

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Authors and Affiliations

  1. Spinal Cord & Brain Injury Research Center (SCoBIRC), University of Kentucky College of Medicine, Lexington, KY, USA

    Edward D. Hall, Juan A. Wang, Jeffrey M. Bosken & Indrapal N. Singh

  2. Anatomy & Neurobiology, Neurosurgery, Neurology and Physical Medicine & Rehabilitation, University of Kentucky Medical Center, Room B477, Biomedical & Biological Sciences Research Building 741 S. Limestone Street, BBSRB Room 477, Lexington, KY, 40536-0509, USA

    Edward D. Hall

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  1. Edward D. Hall
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  2. Juan A. Wang
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  4. Indrapal N. Singh
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Correspondence to Edward D. Hall.

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Hall, E.D., Wang, J.A., Bosken, J.M. et al. Lipid peroxidation in brain or spinal cord mitochondria after injury. J Bioenerg Biomembr 48, 169–174 (2016). https://doi.org/10.1007/s10863-015-9600-5

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  • DOI: https://doi.org/10.1007/s10863-015-9600-5

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