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Solubility Measurements and Prediction of Coenzyme Q10 Solubility in Different Solvent Systems

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Abstract

The solubility of coenzyme Q10 in ethyl acetate, n-hexane, 1-butanol, 1-propanol, 2-propanol and ethanol in the temperature range 270.15–320.15 K, under atmospheric pressure, was measured by a gravimetric method and compared with the data predicted using the conductor like screening model for realistic solvation (COSMO-RS) method. The results show that the solubilities of coenzyme Q10 in the above solvents increase with temperature. The temperature dependences of predicted solubilities were consistent with the experimental data. The experimental data were correlated with the Apelblat equation. At the same temperature, the order of increasing solubility is ethyl acetate > n-hexane > 1-butanol > 1-propanol > 2-propanol > ethanol.

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Acknowledgments

We gratefully acknowledge financial support from the National Natural Science Foundation of China (No.20836005, 21003077 and 21176184) and the Open Project of Key Laboratory Advanced Energy Materials Chemistry (Nankai University) (KLAEMC-OP201201). The ADF program (trial version) was provided by Beijing Hongcam Company.

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Authors and Affiliations

  1. Department of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Yin Zhao, Yan-Hong Sun, Zhi-Yong Li, Chuang Xie, Ying Bao, Zhi-Jian Chen, Jun-Bo Gong, Qiu-Xiang Yin & Wei Chen

  2. Institute of New Catalytic Materials Science, Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin, 300071, China

    Cui Zhang

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  1. Yin Zhao
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  2. Yan-Hong Sun
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Correspondence to Wei Chen.

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Zhao, Y., Sun, YH., Li, ZY. et al. Solubility Measurements and Prediction of Coenzyme Q10 Solubility in Different Solvent Systems. J Solution Chem 42, 764–771 (2013). https://doi.org/10.1007/s10953-013-9998-5

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  • DOI: https://doi.org/10.1007/s10953-013-9998-5

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