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Prospective carriers of 223Ra for targeted alpha particle therapy

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Abstract

We report here on basic aspects that have to be addressed in TAT systems and describe our experiments with prospective carriers of 223Ra intended for bone therapy based on hydroxyapatite nanoparticles. Preparation, in vitro stability tests are described. Labelling yields were ranging between 60–99 % depending on the reaction conditions. Preliminary static stability tests of successfully 223Ra-labelled hydroxyapatite nanoparticles were performed in a physiological saline and showed relatively low activity washout within 24 h (<5 % of total sample activity).

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Acknowledgments

This work was partially supported by the Ministry of Education Youth and Sports of the Czech Republic, grant No.: LK21310, Technological Agency of the Czech Republic Grant No.: TA03010027 and Czech Technical University Grant No.: SGS14/084/OHK4/1D/14.

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Authors and Affiliations

  1. Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Břehová 7, 11519, Prague 1, Czech Republic

    J. Kozempel, M. Vlk, E. Málková, A. Bajzíková & J. Bárta

  2. Laboratory of Nanoradiopharmaceuticals, Institute of Radiopharmacy, Rio De Janeiro, Brazil

    R. Santos-Oliveira

  3. Departamento de Materiais, Centro Brasileiro de Pesquisa Física, Rio De Janeiro, Brazil

    A. Malta Rossi

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  1. J. Kozempel
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  2. M. Vlk
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  3. E. Málková
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  4. A. Bajzíková
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  5. J. Bárta
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  6. R. Santos-Oliveira
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  7. A. Malta Rossi
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Correspondence to J. Kozempel.

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Kozempel, J., Vlk, M., Málková, E. et al. Prospective carriers of 223Ra for targeted alpha particle therapy. J Radioanal Nucl Chem 304, 443–447 (2015). https://doi.org/10.1007/s10967-014-3615-y

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  • DOI: https://doi.org/10.1007/s10967-014-3615-y

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