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Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1

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Abstract

Traditionally, kinesins have been identified as proteins that use the energy of ATP to translocate along microtubules. However, in the last decade some kinesin-like proteins were found to destabilize microtubule ends. The kinesins that destabilize microtubules are known as “catastrophe kinesins”. Analyses of a Xenopus member of the catastrophe kinesins called MCAK/XKCM1 have shown that, in fact, catastrophe kinesins are essential for controlling the distribution of microtubules by inducing their depolymerization. Therefore, unraveling the mechanisms of how microtubule destabilization promoted by these catastrophe kinesins is controlled is essential for understanding how microtubules in a cell are distributed. Here we give an overview of the studies that have focused on the global and local control of microtubule destabilization promoted by MCAK/XKCM1.

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Acknowledgements

We thank Martin Srayko (MPI-CBG) for helpful comments on the manuscript. Our studies described here were supported by a grant from DFG-priority program ‘Molecular Motors’.

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Authors and Affiliations

  1. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, 01307, Dresden, Germany

    Kazuhisa Kinoshita, Tim L. Noetzel, David N. Drechsel & Anthony A. Hyman

  2. Equipe ATIPE, UMR 6026, Université de Rennes 1, Campus de Beaulieu, Bt 13, 35042, Rennes Cedex, France

    Isabelle Arnal

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  1. Kazuhisa Kinoshita
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  2. Tim L. Noetzel
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  3. Isabelle Arnal
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  4. David N. Drechsel
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Correspondence to Kazuhisa Kinoshita.

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Kinoshita, K., Noetzel, T.L., Arnal, I. et al. Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1. J Muscle Res Cell Motil 27, 107–114 (2006). https://doi.org/10.1007/s10974-005-9045-2

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