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Research progress on Livin protein: an inhibitor of apoptosis

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Abstract

Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Abnormal Livin expression is sometimes detected during the process of cancer formation and/or progression. Thus, Livin research may provide an opportunity for the development of potential therapy for Livin-relevant cancers. In this review, we introduce Livin structure, biological function, and its role in cancer formation and progression and the possible interventions for cancer therapy.

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Acknowledgments

We thank the Harvard Medical School to provide the technical platform and the joint PhD student education program between Harvard University (USA) and Tongji University (China). This work was supported by State Scholarship Fund of China (No. 2009626129) from China Scholarship Council (CSC).

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  1. Key Laboratory of Aquatic Genetic Resources and Utilization, Shanghai Ocean University, Huchenghuan Road 999, 201306, Shanghai, China

    Biao Yan

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Yan, B. Research progress on Livin protein: an inhibitor of apoptosis. Mol Cell Biochem 357, 39–45 (2011). https://doi.org/10.1007/s11010-011-0873-7

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