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CCL2 −2518 A/G single nucleotide polymorphism as a risk factor for breast cancer

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Abstract

The contribution of the CCL2 −2518 A>G (rs 1024611) polymorphism in the occurrence and progression of various cancers has been found to be discordant. We studied the prevalence of the CCL2 −2518 A>G polymorphism in patients with breast cancer (n = 160) and controls (n = 323) in a sample of the Polish population. There were no significant differences in CCL2 −2518 A>G genotypes between patients with breast tumors and controls. Odds ratio (OR) for patients bearing the GG genotype was 1.481 (95% CI = 0.7711–2.845, P = 0.2358), and OR of the GG and AG genotypes was 0.7269 (95% CI = 0.4967–1.064, P = 0.1002). There was also no significant distinction in the prevalence of alleles between patients and healthy individuals. OR for the CCL2 −2518 G allele frequency was 0.8903 (95% CI = 0.6611–1.199, P = 0.4441). Analysis of the association between tumor size, lymph node metastases, histological grade, and distribution of genotypes and alleles for the CCL2 −2518 A>G polymorphism also did not show significant differences. Our results did not show association of the CCL2 −2518 A>G polymorphism with breast cancer occurrence and clinical characteristics in a sample of the Polish cohort.

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Acknowledgments

Supported by grant No 502-01-01124182-07474 Poznań University of Medical Sciences.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St, 60-781, Poznań, Poland

    Łukasz Kruszyna, Margarita Lianeri, Błażej Rubis & Paweł P. Jagodziński

  2. Department of Clinical Chemistry and Molecular Diagnostics, Poznań University of Medical Sciences, Poznań, Poland

    Błażej Rubis, Hanna Knuła & Maria Rybczyńska

  3. Department of Oncological Surgery, Department of Oncology, Poznań University of Medical Sciences, Poznań, Poland

    Sylwia Grodecka-Gazdecka

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  1. Łukasz Kruszyna
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  2. Margarita Lianeri
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Correspondence to Paweł P. Jagodziński.

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Kruszyna, Ł., Lianeri, M., Rubis, B. et al. CCL2 −2518 A/G single nucleotide polymorphism as a risk factor for breast cancer. Mol Biol Rep 38, 1263–1267 (2011). https://doi.org/10.1007/s11033-010-0225-9

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  • DOI: https://doi.org/10.1007/s11033-010-0225-9

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