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Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers

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Abstract

Lung cancer is the most common cause of cancer death worldwide. Smoking is known as the strongest single factor in the development of lung cancer. However, there are inherited genetic factors that cause different responses to cigarette smoking exposure among individuals. We tried to identify these differences in heavy smokers by examining copy number variations (CNVs) between lung cancer patients and healthy controls. Analysis by array comparative genomic hybridization which was tested with 20-person training set (10 lung cancer patients, 10 healthy controls) showed 26 significant (adjusted P < 0.05) clones with either copy number gains or losses. Three genes, KCTD11, FGF11, and PTPRH on chromosomal regions 17p13.1 (KCTD11 and FGF11) and 19q13.42 (PTPRH), were selected (adjusted P < 0.001) and tested by real-time quantitative PCR with 34 healthy controls and 54 lung cancer patients. KCTD11 on the chromosomal region 17p13.1 showed significant high odds ratio (OR = 16.0) in heavy smokers, implying that this is a susceptibility region for lung cancer in this group. Therefore, CNVs of 17p13.1 is a promising candidate to identify individuals with a high genetic risk for the development of lung cancer.

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Acknowledgments

This study was supported by a grant (A084127) from the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea and, in part, by the Konyang University Myunggok Research Fund of 2010-06.

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Authors and Affiliations

  1. Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, 302-718, Republic of Korea

    Minhyeok Lee, Yeiwon Lee, Chang-Gyo Park, Hoi-Young Lee, Ji-Woong Son & Jaeku Kang

  2. Department of Laboratory Medicine, Konyang University Hospital, Daejeon, 302-718, Republic of Korea

    Hyun-Jung Cho

  3. Department of Preventive Medicine, College of Medicine, Konyang University, Daejeon, 302-718, Republic of Korea

    Jeeyoung Hong

  4. Department of Internal Medicine, Konyang University Hospital, Daejeon, 302-718, Republic of Korea

    Sun-Jung Kwon & Ji-Woong Son

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  1. Minhyeok Lee
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Correspondence to Ji-Woong Son or Jaeku Kang.

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Minhyeok Lee and Yeiwon Lee contributed equally to this work.

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Lee, M., Lee, Y., Cho, HJ. et al. Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers. Mol Biol Rep 38, 5211–5217 (2011). https://doi.org/10.1007/s11033-010-0672-3

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  • DOI: https://doi.org/10.1007/s11033-010-0672-3

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