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NutriTRAILomics in prostate cancer: time to have two strings to one’s bow

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Abstract

The astonishing development of broad genomics and proteomics tools have catalyzed a new era in both therapeutic interventions and nutrition in prostate cancer. The terms pharmacogenomics and nutrigenomics have been derived out of their genetic forbears as large-scale genomics technologies have been established in the last decade. It is unquestionable that rationale of both disciplines is to individualize or personalize medicine and food and nutrition, and eventually health, by tailoring the drug or the food to the individual genotype. The purpose of this review is to significantly inspect results from current research concerning the mechanisms of action of phytonutrients and potential effects on prostate cancer. Substantial emerging data supports the synergistic adiministration of nutraceuticals with TRAIL in prostate cancer progression to circumvent TRAIL refractoriness. Nonetheless, developing novel scientific methods for discovery, validation, characterization and standardization of these multicomponent phyto-therapeutics is vital to their recognition into mainstream medicine. The key to interpret a personalized response is a greater comprehension of nutrigenomics, proteomics and metabolomics.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan

    Ammad Ahmad Farooqi, Asma M. Riaz, Muhammad Ali, Sara Javed, Shahzeray Mukhtar, Sehrish Minhaj, Javeria Rafique Rao, Javairia Rajpoot, Rafia Amber, Fiza Asif Javed,  Waqar-un-Nisa, Reema Khanum & Shahzad Bhatti

  2. NUST Centre of Virology and Immunology (NCVI), National University of Science and Technology, Islamabad, Pakistan

    Aamir Rana & Ammara Khan

Authors
  1. Ammad Ahmad Farooqi
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  2. Aamir Rana
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  3. Asma M. Riaz
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  13. Waqar-un-Nisa
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  14. Reema Khanum
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  15. Shahzad Bhatti
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Corresponding author

Correspondence to Ammad Ahmad Farooqi.

Additional information

Ammad Ahmad Farooqi, Shahzad Bhatti authors contributed equally to this work.

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Farooqi, A.A., Rana, A., Riaz, A.M. et al. NutriTRAILomics in prostate cancer: time to have two strings to one’s bow. Mol Biol Rep 39, 4909–4914 (2012). https://doi.org/10.1007/s11033-011-1286-0

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  • DOI: https://doi.org/10.1007/s11033-011-1286-0

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