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Genetic variants of GRIA1 are associated with susceptibility to schizophrenia in Korean population

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Abstract

The α-amino-3-hydroxy-5-methyl-4-propionic acid (AMPA) receptors are important for glutamate synaptic transmission in the central nervous system. Glutamate receptor, ionotropic, AMPA receptor 1 gene (GRIA1) belongs to the family of AMPA receptors. There is increasing evidence that AMPA receptors dysfunction may be related to an increased susceptibility to schizophrenia. The aim of this study was therefore to investigate whether genetic polymorphisms of GRIA1 are associated with schizophrenia and their clinical symptoms (hallucinations and delusions) in Korean population. Five single nucleotide polymorphisms (rs1428920, rs1552834, rs1422889, rs10035143, and rs2926835) of the GRIA1 were genotyped in 218 schizophrenia patients and 380 healthy controls, using a direct sequencing. All patients were evaluated by the Operational Criteria Checklist for Psychotic Illness. The genotype and allelic frequencies of rs1428920 and rs2926835 showed significant association between schizophrenia and controls (rs1428920, permutation p = 0.008, 0.008; rs2926835, permutation p = 0.038, 0.041, respectively). A significantly increased risk of schizophrenia was associated with the A allele of rs1428920 and rs2926835 of GRIA1. Furthermore, we found that rs1428920 was weakly associated with hallucinations of schizophrenia, but this significance disappeared after multiple testing (permutation p = 0.119). These results suggest that GRIA1 polymorphism may have influence upon the risk of developing schizophrenia.

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Acknowledgments

This work was supported by a Grant from the Kyung Hee University (KHU-20090641).

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Authors and Affiliations

  1. Department of Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Won Sub Kang, Jin Kyung Park, Sang Min Lee, Ji Young Song & Jong Woo Kim

  2. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Su Kang Kim, Hae Jeong Park & Joo-Ho Chung

Authors
  1. Won Sub Kang
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  2. Jin Kyung Park
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  3. Su Kang Kim
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  4. Hae Jeong Park
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  5. Sang Min Lee
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  6. Ji Young Song
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  7. Joo-Ho Chung
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  8. Jong Woo Kim
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Correspondence to Jong Woo Kim.

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Kang, W.S., Park, J.K., Kim, S.K. et al. Genetic variants of GRIA1 are associated with susceptibility to schizophrenia in Korean population. Mol Biol Rep 39, 10697–10703 (2012). https://doi.org/10.1007/s11033-012-1960-x

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  • DOI: https://doi.org/10.1007/s11033-012-1960-x

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