Skip to main content
SpringerLink
Log in

The KCNJ11 E23K gene polymorphism and type 2 diabetes mellitus in the Chinese Han population: a meta-analysis of 6,109 subjects

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene polymorphism has been indicated as relevant to type 2 diabetes mellitus (T2D) susceptibility, but research results remain debatable.To investigate the relationship between KCNJ11 E23K gene polymorphism and T2D in the Chinese Han population, a meta-analysis involving 3,080 T2D patients and 3,029 controls from five separate studies was conducted. The pooled odds ratio (ORs) for the association between KCNJ11 E23K gene polymorphism and T2D and its corresponding 95 % confidence interval (95 % CI) were estimated using a random effects model.A significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the pooled Chinese Han population through an allelic genetic model (OR: 1.21, 95 % CI: 1.04–1.40, P = 0.01) and a recessive genetic model (OR: 1.44, 95 % CI: 1.25–1.65, P < 0.00001). In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41–1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Ashcroft FM, Harrison DE, Ashcroft SJ (1984) Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature 312:446–448

    Article  PubMed  CAS  Google Scholar 

  2. Inagaki N, Gonoi T, Clement JP 4th, Namba N, Inazawa J et al (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270:1166–1170

    Article  PubMed  CAS  Google Scholar 

  3. Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA et al (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52:568–572

    Article  PubMed  CAS  Google Scholar 

  4. Koo BK, Cho YM, Park BL, Cheong HS, Shin HD et al (2007) Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population. Diabet Med 24:178–186

    Article  PubMed  CAS  Google Scholar 

  5. Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T et al (2003) The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 52:573–577

    Article  PubMed  CAS  Google Scholar 

  6. Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T et al (2006) Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Diabetes 55:2379–2386

    Article  PubMed  CAS  Google Scholar 

  7. Wang F, Han XY, Ren Q, Zhang XY, Han LC et al (2009) Effect of genetic variations in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population. Chin Med J 122:2477–2482

    PubMed  CAS  Google Scholar 

  8. Wang GF, Jiang WJ, Jiang XB, Wu YL, Zhang DF et al (2011) Correlation study of KCNJ11 gene E23K polymorphism with type 2 diabetes mellitus. Acta Academiae Medicinae Qingdao Universitatis 47:104–107

    Google Scholar 

  9. Cochran WG (1968) The effectiveness of adjustment by subclassification in removing bias in observational studies. Biometrics 24:295–313

    Article  PubMed  CAS  Google Scholar 

  10. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748

    PubMed  CAS  Google Scholar 

  11. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  PubMed  CAS  Google Scholar 

  12. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    Article  PubMed  CAS  Google Scholar 

  13. Zhou D, Zhang D, Liu Y, Zhao T, Chen Z et al (2009) The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population. J Hum Genet 54:433–435

    Article  PubMed  CAS  Google Scholar 

  14. Liu LF, Lei JJ, Liu HY, Zou QJ, Sun YH et al (2010) Identification of susceptibility gene loci associated with type 2 diabetes. Wuhan Univ J Nat Sci 15:171–175

    Article  CAS  Google Scholar 

  15. Liu ML, Dong JQ (2011) Correlation of membrane glycoprotein Kir6.2 gene polymorphism with type 2 diabetes mellitus and insulin resistance in Han Nationality in Shenzhen. Chin J Prev Contr Chron Dis 9:123–125

    Google Scholar 

  16. John SA, Weiss JN, Xie LH, Ribalet B (2003) Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2. J Physiol 552:23–34

    Article  PubMed  CAS  Google Scholar 

  17. Alsmadi O, Al-Rubeaan K, Wakil SM, Imtiaz F, Mohamed G et al (2008) Genetic study of Saudi diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes. Diabetes Metab Res Rev 24:137–140

    Article  PubMed  CAS  Google Scholar 

  18. Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV et al (2009) Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes. Acta Diabetol 46:43–49

    Article  PubMed  CAS  Google Scholar 

  19. Cejková P, Novota P, Cerná M, Kolostová K, Nováková D et al (2007) KCNJ11 E23K polymorphism and diabetes mellitus with adult onset in Czech patients. Folia Biol (Praha) 53:173–175

    Google Scholar 

Download references

Acknowledgments

This work was funded by the National Natural Science Foundation of China (NSFC 81100073 to Dr Yan-yan Li) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). Thank all our colleagues working in the Department of geriatrics, the First Affiliated Hospital of Nanjing Medical University.

Author information

Authors and Affiliations

  1. Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Yan-yan Li

Authors
  1. Yan-yan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yan-yan Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, Yy. The KCNJ11 E23K gene polymorphism and type 2 diabetes mellitus in the Chinese Han population: a meta-analysis of 6,109 subjects. Mol Biol Rep 40, 141–146 (2013). https://doi.org/10.1007/s11033-012-2042-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-012-2042-9

Keywords

Search

Navigation