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DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population

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Abstract

Behcet’s disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p < 0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD genotype could be a genetic marker in BD in Turkish study population.

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Authors and Affiliations

  1. Department of Medical Biology, Faculty of Medicine, Gaziosmapaşa University, Tokat, Turkey

    Serbülent Yigit, Aydin Rüstemoglu, Songul Akkanet & Ömer Ateş

  2. Section of Medical Genetics, Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, 55130, Samsun, Turkey

    Sengül Tural & Nevin Karakuş

  3. Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Gaziosmapaşa University, Tokat, Turkey

    Ahmet Inanir

  4. Second Dermatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey

    Ulker Gul

  5. Department of Dermatology, Faculty of Medicine, Gaziosmapaşa University, Tokat, Turkey

    Goknur Kalkan

Authors
  1. Serbülent Yigit
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  2. Sengül Tural
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  3. Aydin Rüstemoglu
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  4. Ahmet Inanir
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  5. Ulker Gul
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  6. Goknur Kalkan
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  7. Songul Akkanet
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  8. Nevin Karakuş
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  9. Ömer Ateş
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Correspondence to Sengül Tural.

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Yigit, S., Tural, S., Rüstemoglu, A. et al. DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population. Mol Biol Rep 40, 365–368 (2013). https://doi.org/10.1007/s11033-012-2069-y

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  • DOI: https://doi.org/10.1007/s11033-012-2069-y

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