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Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients

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Abstract

A deletion of two genes from the late cornified envelope (LCE), LCE3B and LCE3C within epidermal differentiation complex on chromosome 1 was shown to be associated with both psoriasis and psoriatic arthritis (PsA) in several populations. To assess whether this deletion may contribute to the genetic predisposition to PsA in Tunisia, a total of 73 patients with PsA and 120 healthy matched controls were screened for the deletion, LCE3C_LCE3B-del, and its tag SNP, rs4112788. We also evaluated a possible relationship between PSORS1 and LCE3C_LCE3B-del through genotyping two proxy markers to HLA-C (rs12191877 and rs2073048). Our results did not provide evidence for association between the LCE3C_LCE3B-del nor the rs4112788 and the PsA. Similarly, no significant epistatic effect was observed. Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients supporting the current perception that different genetic risk factors contribute to skin and joint disease. However, these results need to be confirmed by additional large-scale studies of Tunisian PsA patients and controls.

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Acknowledgments

We thank the patients and family members. This work was supported by the Tunisian Ministry of Scientific and Technological Research and, Development of Competencies (Laboratory of Genetics, Immunology and Human Pathologies).

Conflict of interest

We state that we have no commercial affiliations, consultancies, stock or equity interests and patent-licensing arrangements that could be considered to pose a conflict of interest regarding the submitted article. We state that this work has been approved by the local Research Ethics Committee of la Rabta Hospital of Tunis. The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences, University of Tunis El Manar, 2092, Tunis, Tunisia

    Bouchlaka Souissi Chiraz, Ammar Myriam, Bouazizi Fatma & Elgaaied Amel

  2. Dermatology Department, La Rabta Hospital, 1007, Tunis, Tunisia

    Zarra Ines

  3. Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Jordan Catherine & Helms Cindy

  4. Osteoarthritis-osteoporosis Research Laboratory, Rheumatology Department, LaRabta Hospital, 1007, Tunis, Tunisia

    Cheour Ilhem & Sellami Slaheddine

  5. Rheumatology Department, Charles Nicolle Hospital, 1006, Tunis, Tunisia

    Tekaya Raoudha

  6. Rheumatology Department, Farhat Hached Hospital, 4000, Sousse, Tunisia

    Zeglaoui Hela & Bouajina Elyes

  7. Rheumatology Department, Hedi Chaker Hospital, 3029, Sfax, Tunisia

    Fourati Hela

  8. Dermatology Department, Military Hospital, 1008, Tunis, Tunisia

    Doss Nejib

Authors
  1. Bouchlaka Souissi Chiraz
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  2. Ammar Myriam
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Correspondence to Bouchlaka Souissi Chiraz.

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Chiraz, B.S., Myriam, A., Ines, Z. et al. Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients. Mol Biol Rep 41, 4141–4146 (2014). https://doi.org/10.1007/s11033-014-3285-4

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  • DOI: https://doi.org/10.1007/s11033-014-3285-4

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