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Prognostic Potential of the Panfungal Marker (1 → 3)-β-d-Glucan in Invasive Mycoses Patients

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Abstract

We analyze the prognostic potential of (1 → 3)-β-d-glucan (BG) levels in predicting clinical outcomes in patients with invasive fungal infections, on a population undergoing 253 episodes (177 with positive and 76 with negative outcome). Using linear regression analysis, we assessed the prognostic potential of kinetically evaluated BG levels and we found an overall sensitivity and specificity of 68 and 82%, respectively. Moreover, using an interpretative algorithm based on two distinct cutoff values, we were able to predict the outcome in 84% of the studied population with a diagnostic accuracy of 82%.

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Authors and Affiliations

  1. Dipartimento di Medicina Diagnostica, Clinica e di Sanità Pubblica, Istituti Biologici, Università degli Studi di Modena e Reggio Emilia, Via Campi 287, 41125, Modena, Italy

    P. Pini & E. Blasi

  2. Azienda Ospedaliero Universitaria-Policlinico, Modena, Italy

    P. Pini, C. Venturelli, M. Girardis, F. Forghieri & E. Blasi

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  1. P. Pini
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  2. C. Venturelli
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  3. M. Girardis
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  4. F. Forghieri
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  5. E. Blasi
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Corresponding author

Correspondence to E. Blasi.

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The authors declare that they have no conflict of interest.

Ethical Approval

All the procedures performed in the study, involving elaboration of data obtained from biological samples, were in accordance with the ethical standards of the local institutional research committee (regularly approved protocols Nos. 53/11 and 251/17) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Handling Editor: Vishnu Chaturvedi.

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Pini, P., Venturelli, C., Girardis, M. et al. Prognostic Potential of the Panfungal Marker (1 → 3)-β-d-Glucan in Invasive Mycoses Patients. Mycopathologia 184, 147–150 (2019). https://doi.org/10.1007/s11046-018-0282-5

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  • DOI: https://doi.org/10.1007/s11046-018-0282-5

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