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Periostin: a novel prognostic predictor for meningiomas

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Abstract

The expression and role of periostin in meningiomas remains unknown. Tissue specimens of 175 convexity meningiomas were immunohistochemically examined with antibodies against periostin and Ki67. The expression levels of periostin and Ki67 were compared among different WHO groups. The role of periostin and Ki67 in postoperative prognosis of meningiomas was also analyzed. Negative (−) expression of Ki67 was observed in 101 (57.7 %) cases of all the surgical tissue samples. The Ki67 expressions differed significantly among the WHO groups (P < 0.001) and correlated positively with the WHO grade (r = 0.673, P < 0.001). Low/negative staining of periostin was observed in 116 (66.3 %) cases. The periostin expressions differed significantly among the WHO groups (P < 0.001). Periostin expression correlated positively with the WHO grade (r = 0.742, P < 0.001). There was a positive correlation between Ki67 expression and periostin (r = 0.513, P < 0.001). Both Ki67 expression and periostin expression was found statistically different between brain invasion tumor and non-invasion tumor (p < 0.001). The recurrence rate and PFS rate in both varied Ki67 expression groups and periostin expression groups was statistically different (P < 0.001). The survival time and PFS time in both varied Ki67 expression groups and periostin expression groups was also statistically different (P < 0.001). Periostin was expressed in tumor stroma of meningiomas. Both periostin and Ki67 may behave as a maker in predicting the grade and prognosis in meningiomas. Drugs that targets periostin aims at reducing invasion of meningioma patients should be further researched.

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References

  1. Bondy M, Ligon BL (1996) Epidemiology and etiology of intracranial meningiomas: a review. J Neurooncol 29:197–205

    Article  CAS  PubMed  Google Scholar 

  2. Fuller GN, Scheithauer BW (2007) The 2007 revised World Health Organization (WHO) classification of tumours of the central nervous system: newly codified entities. Brain Pathol 17:304–307

    Article  PubMed  Google Scholar 

  3. Durand A, Labrousse F, Jouvet A, Bauchet L, Kalamarides M, Menei P, Deruty R, Moreau JJ, Fevre-Montange M, Guyotat J (2009) WHO grade II and III meningiomas: a study of prognostic factors. J Neurooncol 95:367–375

    Article  PubMed  Google Scholar 

  4. Vranic A, Popovic M, Cor A, Prestor B, Pizem J (2010) Mitotic count, brain invasion, and location are independent predictors of recurrence-free survival in primary atypical and malignant meningiomas: a study of 86 patients. Neurosurgery 67:1124–1132

    Article  PubMed  Google Scholar 

  5. Weber DC, Lovblad KO, Rogers L (2010) New pathology classification, imagery techniques and prospective trials for meningiomas: the future looks bright. Curr Opin Neurol 23:563–570

    Article  PubMed  Google Scholar 

  6. Ohba S, Kobayashi M, Horiguchi T, Onozuka S, Yoshida K, Ohira T, Kawase T (2011) Long-term surgical outcome and biological prognostic factors in patients with skull base meningiomas. J Neurosurg 114:1278–1287

    PubMed  Google Scholar 

  7. Nakasu S, Fukami T, Jito J, Nozaki K (2009) Recurrence and regrowth of benign meningiomas. Brain Tumor Pathol 26:69–72

    Article  PubMed  Google Scholar 

  8. Takeshita S, Kikuno R, Tezuka K, Amann E (1993) Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J 294(Pt 1):271–278

    CAS  PubMed Central  PubMed  Google Scholar 

  9. Ruan K, Bao S, Ouyang G (2009) The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci 66:2219–2230

    Article  CAS  PubMed  Google Scholar 

  10. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF (2004) Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell 5:329–339

    Article  CAS  PubMed  Google Scholar 

  11. Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR (2007) Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway. Oncogene 26:2082–2094

    Article  CAS  PubMed  Google Scholar 

  12. Gunia S, Jain A, Koch S, Denzinger S, Gotz S, Niessl N, May M (2013) Periostin expression correlates with pT-stage, grading and tumour size, and independently predicts cancer-specific survival in surgically treated penile squamous cell carcinomas. J Clin Pathol 66:297–301

    Article  CAS  PubMed  Google Scholar 

  13. Kim CJ, Sakamoto K, Tambe Y, Inoue H (2011) Opposite regulation of epithelial-to-mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells. Int J Oncol 38:1759–1766

    CAS  PubMed  Google Scholar 

  14. Kudo Y, Ogawa I, Kitajima S, Kitagawa M, Kawai H, Gaffney PM, Miyauchi M, Takata T (2006) Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Cancer Res 66:6928–6935

    Article  CAS  PubMed  Google Scholar 

  15. Nuzzo PV, Rubagotti A, Zinoli L, Ricci F, Salvi S, Boccardo S, Boccardo F (2012) Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death. BMC Cancer 12:625

    Article  PubMed Central  PubMed  Google Scholar 

  16. Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, Gishizky ML, Marks JR, Wang XF (2004) Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol 24:3992–4003

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Siriwardena BS, Kudo Y, Ogawa I, Kitagawa M, Kitajima S, Hatano H, Tilakaratne WM, Miyauchi M, Takata T (2006) Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. Br J Cancer 95:1396–1403

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Sun C, Zhao X, Xu K, Gong J, Liu W, Ding W, Gou Y, Xia G, Ding Q (2011) Periostin: a promising target of therapeutical intervention for prostate cancer. J Transl Med 9:99

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Takanami I, Abiko T, Koizumi S (2008) Expression of periostin in patients with non-small cell lung cancer: correlation with angiogenesis and lymphangiogenesis. Int J Biol Markers 23:182–186

    CAS  PubMed  Google Scholar 

  20. Tischler V, Fritzsche FR, Wild PJ, Stephan C, Seifert HH, Riener MO, Hermanns T, Mortezavi A, Gerhardt J, Schraml P, Jung K, Moch H, Soltermann A, Kristiansen G (2010) Periostin is up-regulated in high grade and high stage prostate cancer. BMC Cancer 10:273

    Article  PubMed Central  PubMed  Google Scholar 

  21. Tsunoda T, Furusato B, Takashima Y, Ravulapalli S, Dobi A, Srivastava S, McLeod DG, Sesterhenn IA, Ornstein DK, Shirasawa S (2009) The increased expression of periostin during early stages of prostate cancer and advanced stages of cancer stroma. Prostate 69:1398–1403

    Article  CAS  PubMed  Google Scholar 

  22. Hasseleid BF, Meling TR, Ronning P, Scheie D, Helseth E (2012) Surgery for convexity meningioma: simpson Grade I resection as the goal: clinical article. J Neurosurg 117:999–1006

    Article  PubMed  Google Scholar 

  23. Qi ST, Liu Y, Pan J, Chotai S, Fang LX (2012) A radiopathological classification of dural tail sign of meningiomas. J Neurosurg 117:645–653

    Article  PubMed  Google Scholar 

  24. Jensen R, Lee J (2012) Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation. Neurosurgery 71:146–156

    Article  PubMed  Google Scholar 

  25. Morra L, Moch H (2011) Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update. Virchows Arch 459:465–475

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Yan W, Shao R (2006) Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. J Biol Chem 281:19700–19708

    Article  CAS  PubMed  Google Scholar 

  27. Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (2002) Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. Cancer Res 62:5358–5364

    CAS  PubMed  Google Scholar 

  28. Wilisch-Neumann A, Kliese N, Pachow D, Schneider T, Warnke JP, Braunsdorf WE, Bohmer FD, Hass P, Pasemann D, Helbing C, Kirches E, Mawrin C (2013) The integrin inhibitor cilengitide affects meningioma cell motility and invasion. Clin Cancer Res 19:5402–5412

    Article  CAS  PubMed  Google Scholar 

  29. Abry E, Thomassen IO, Salvesen OO, Torp SH (2010) The significance of Ki-67/MIB-1 labeling index in human meningiomas: a literature study. Pathol Res Pract 206:810–815

    Article  CAS  PubMed  Google Scholar 

  30. Rezanko T, Akkalp AK, Tunakan M, Sari AA (2008) MIB-1 counting methods in meningiomas and agreement among pathologists. Anal Quant Cytol Histol 30:47–52

    PubMed  Google Scholar 

  31. Taddei GL, Caldarella A, Raspollini MR, Taddei A, Buccoliero AM (2002) Estrogen and progesterone receptors in meningiomas: immunohistochemical (Mib-1, p53) and clinico-morphological correlations. Pathologica 94:10–15

    CAS  PubMed  Google Scholar 

  32. Kim Y, Stolarska MA, Othmer HG (2011) The role of the microenvironment in tumor growth and invasion. Prog Biophys Mol Biol 106:353–379

    Article  PubMed Central  PubMed  Google Scholar 

  33. Koontongkaew S (2013) The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas. J Cancer 4:66–83

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  34. Ng YZ, South AP (2014) Tissue engineering of tumor stromal microenvironment with application to cancer cell invasion. J Vis Exp. doi:10.3791/51321

    PubMed  Google Scholar 

  35. Li M, Li C, Li D, Xie Y, Shi J, Li G, Guan Y, Li M, Zhang P, Peng F, Xiao Z, Chen Z (2012) Periostin, a stroma-associated protein, correlates with tumor invasiveness and progression in nasopharyngeal carcinoma. Clin Exp Metastasis 29:865–877

    Article  PubMed  Google Scholar 

  36. Hong LZ, Wei XW, Chen JF, Shi Y (2013) Overexpression of periostin predicts poor prognosis in non-small cell lung cancer. Oncol Lett 6:1595–1603

    CAS  PubMed Central  PubMed  Google Scholar 

  37. Utispan K, Sonongbua J, Thuwajit P, Chau-In S, Pairojkul C, Wongkham S, Thuwajit C (2012) Periostin activates integrin alpha5beta1 through a PI3K/AKTdependent pathway in invasion of cholangiocarcinoma. Int J Oncol 41:1110–1118

    CAS  PubMed  Google Scholar 

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Conflict of interest

All the authors report no conflicts of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, China

    Yi Liu, Jin Shi, Ming Chen, Yong-fu Cao, Ya-wei Liu, Jun Pan & Song-tao Qi

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  1. Yi Liu
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  2. Jin Shi
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  3. Ming Chen
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  4. Yong-fu Cao
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  5. Ya-wei Liu
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  6. Jun Pan
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  7. Song-tao Qi
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Correspondence to Jun Pan or Song-tao Qi.

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Yi Liu, Jin Shi and Ming Chen are co-first authors.

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Liu, Y., Shi, J., Chen, M. et al. Periostin: a novel prognostic predictor for meningiomas. J Neurooncol 121, 505–512 (2015). https://doi.org/10.1007/s11060-014-1678-9

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  • DOI: https://doi.org/10.1007/s11060-014-1678-9

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