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Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

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Abstract

Extracellular accumulations of Aβ, hyperphosphorylation of tau and intracellular neurofibrillary tangle formation have been the hallmarks of Alzheimer’s Disease (AD). Although tau and its phosphorylation play a pivotal role in the normal physiology yet its hyperphosphorylation has been a pathological manifestation in neurodegenerative disorders like AD. In this review physiology of tau, its phosphorylation, hyperphosphorylation with the intervention of various kinases, aggregation and formation of paired helical filaments has been discussed. A brief account of various animal models employed to study the pathological manifestation of tau in AD and therapeutic strategies streamlined to counter the tau induced pathology has been given. The reasons for the failure to have suitable animal model to study AD pathology and recent success in achieving this has been included. The role of caspase cascade in tau cleavage has been emphasized. The summary of current studies on tau and the need for future studies has been accentuated.

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Acknowledgments

Authors sincerely thank Dr. Joseph, Chairman, Garden City Group of Institutions, Bangalore for his generous support.

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Authors and Affiliations

  1. Department of Biotechnology, Rayalaseema University, Kurnool, India

    M. Obulesu

  2. Department of Biotechnology, Capital College, Garden City Group of Institutions, Bangalore, India

    R. Venu & R. Somashekhar

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  1. M. Obulesu
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  2. R. Venu
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Correspondence to M. Obulesu.

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Obulesu, M., Venu, R. & Somashekhar, R. Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology. Neurochem Res 36, 1329–1335 (2011). https://doi.org/10.1007/s11064-011-0475-5

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