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Valproic Acid: A New Candidate of Therapeutic Application for the Acute Central Nervous System Injuries

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Abstract

Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI), and spinal cord injury (SCI), are common causes of human disabilities and deaths, but the pathophysiology of these diseases is not fully elucidated and, thus, effective pharmacotherapies are still lacking. Valproic acid (VPA), an inhibitor of histone deacetylation, is mainly used to treat epilepsy and bipolar disorder with few complications. Recently, the neuroprotective effects of VPA have been demonstrated in several models of acute CNS injuries, such as stroke, TBI, and SCI. VPA protects the brain from injury progression via anti-inflammatory, anti-apoptotic, and neurotrophic effects. In this review, we focus on the emerging neuroprotective properties of VPA and explore the underlying mechanisms. In particular, we discuss several potential related factors in VPA research and present the opportunity to administer VPA as a novel neuropective agent.

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Acknowledgments

This study was supported by National Natural Science Foundation of China (No.81171096 and No.81371433) to JM Zhang and by National Natural Science Foundation of China (No. 81371369) to Y Hong.

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The authors report no conflicts of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China

    Sheng Chen, Haijian Wu, Yuan Hong & Jianmin Zhang

  2. Departments of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA

    Damon Klebe

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  1. Sheng Chen
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  2. Haijian Wu
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  3. Damon Klebe
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  4. Yuan Hong
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Correspondence to Jianmin Zhang.

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Sheng Chen and Haijian Wu contribute equally to the work.

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Chen, S., Wu, H., Klebe, D. et al. Valproic Acid: A New Candidate of Therapeutic Application for the Acute Central Nervous System Injuries. Neurochem Res 39, 1621–1633 (2014). https://doi.org/10.1007/s11064-014-1241-2

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  • DOI: https://doi.org/10.1007/s11064-014-1241-2

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