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Drug Delivery Using Platelet Cancer Cell Interaction

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Abstract

Purpose

To develop an efficient biocompatible and targeted drug delivery system in which platelets, an essential blood component having a natural affinity for cancer cells, are used as carrier of anticancer drug as delivery of drug to the targeted site is crucial for cancer treatment.

Methods

Doxorubicin hydrochloride, a potent anti cancer drug, was delivered in lung adenocarcinoma cell line (A549) using platelet as a delivery agent. This delivery mode was also tested in Ehrlich ascites carcinoma (EAC) bearing mice in presence and absence of platelets.

Results

The results show that platelets can uptake the drug and release the same upon activation. The efficiency of drug loaded platelets in inducing cytotoxicity was significantly higher in both in vitro and in vivo model, as compared to the free drug.

Conclusions

The proposed drug delivery strategy may lead to clinical improvement in the management of cancer treatment as lower drug concentration can be used in a targeted mode. Additionally the method can be personalized as patient's own platelet can be used for deliver various drugs.

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Abbreviations

Dox:

Doxorubicin hydrochloride

EAC:

Ehrlich ascites carcinoma

PPP:

Platelet poor plasma

PRP:

Platelet rich plasma

WP:

Washed platelet

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Acknowledgments and Disclosures

We thank ICMR, India (grant no. 45/06/2011/NAN-BMS) for supporting the research. We thank Dr. Suryyani Deb Dr. Hirak Kr Patra (Calcutta University) and Ms. Puja Biswas (DBT,IPLS) for their suggestions and help.

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Authors and Affiliations

  1. Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, 700019, India

    Sounik Sarkar, Jyoti Shaw & Anjan Kr. Dasgupta

  2. Department of Microbiology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, 700019, India

    Mohammed Aftab Alam

Authors
  1. Sounik Sarkar
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  2. Mohammed Aftab Alam
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  3. Jyoti Shaw
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  4. Anjan Kr. Dasgupta
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Corresponding author

Correspondence to Anjan Kr. Dasgupta.

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Sarkar, S., Alam, M.A., Shaw, J. et al. Drug Delivery Using Platelet Cancer Cell Interaction. Pharm Res 30, 2785–2794 (2013). https://doi.org/10.1007/s11095-013-1097-1

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  • DOI: https://doi.org/10.1007/s11095-013-1097-1

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