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Comparative Efficacy of Different Anthelmintics Against Fenbendazole-Resistant Nematodes of Pashmina Goats

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Abstract

A trial using albendazole, albendazole plus rafoxanide combination, ivermectin and doramectin was conducted in Pashmina goats having history of fenbendazole resistance to Haemonchus spp. and maintained at high altitude (>2350 m above sea level). Day 0 infection level was variable in different groups of animals and their larval cultures indicated Haemonchus, Trichostrongylus, Ostertagia and Oesophagostomum spp. infection, in addition to Nematodirus spp. as observed in egg counts. Efficacy of drugs was calculated on day 14 post treatment by faecal egg count reduction test (FECRT). Albendazole was least effective (14%) followed by its combination with rafoxanide (54%). However, ivermectin and doramectin were 96% and 94% effective against gastrointestinal nematodes of Pashmina goats. It was concluded that use of albendazole and its combination with rafoxanide are ineffective in controlling the nematodes of goats at this farm; hence, future use must be avoided. However, regular monitoring of the efficacy of ivermectin and doramectin is needed.

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Abbreviations

ABZ:

albendazole

ARC:

albendazole-plus-rafoxanide combination

bw:

body weight

DRM:

doramectin

FEC:

faecal egg count

FECRT:

faecal egg count reduction test

GI:

gastrointestinal

IVM:

ivermectin

References

  • Banerjee, P.S., Ram, H., Singh, B., Yadav, C.L. and Garg. R., 2002. Efficacy of ivermectin (oral and injectable) and fenbendazole against G.I. nematodes of equines. Centaur, XIX(20), 35–38

    Google Scholar 

  • Bjørn, H., 1994. Workshop summary: anthelmintic resistance. Veterinary Parasitology, 54, 321–325

    Google Scholar 

  • Coles, G.C., Warner, A.K. and Best, J.R., 1996. Triple resistant Ostertagia from Angora goats. The Veterinary Record, 139, 299–300

    PubMed  CAS  Google Scholar 

  • Grimshaw, W.T.R., Hong, C. and Hunt, K.R., 1996. Potential of misinterpretation of the faecal egg count reduction test for levamisole resistance in gastrointestinal nematodes of sheep. Veterinary Parasitology, 62, 267–273

    Article  PubMed  CAS  Google Scholar 

  • Jackson, F., Jackson, E. and Coop, R.L., 1991. Evidence of multiple anthelmintic resistance in a strain of Teladorsagia circumcincta (Ostertagia circumcincta) isolated from goats in Scotland. Research in Veterinary Science, 53, 371–374

    Google Scholar 

  • Laha, R., Hemaprasanth and Harbola, P.C., 1999. Anthelmintic resistance in Pashmina (Cashmere) producing goats in India. Veterinary Research Communications, 23, 187–189

    Article  PubMed  CAS  Google Scholar 

  • Miller, D.K. and Craig, T.M., 1996. Use of anthelmintic combination against multiple resistant Haemonchus contortus in Angora goats. Small Ruminant Research, 19, 281–283

    Article  Google Scholar 

  • Mukerjee, R., Laha, R., Bhattacharya, D. and Mukerjee, R., 1994. Comparative efficacy of tetramisole, fenbendazole and ivermectin against gastrointestinal nematode infection in Pashmina (Cashmere) goat. Indian Journal of Animal Health, 33(2), 125–127

    Google Scholar 

  • Praslicka, J., Varady, M. and Cobra, J., 1994. Persistent infection with multiple anthelmintic resistant gastrointestinal nematodes in Cashmere goats. Veterinary Research Communications, 18, 443–446

    Article  PubMed  CAS  Google Scholar 

  • Raman, M., Sivashanker, R., Vasudevan, R., Lalitha, J. and Rajavelu, G., 2004. Endectocidal activity of doramectin against parasites of swine. Journal of Veterinary Parasitology, 18(2), 139–142

    Google Scholar 

  • Soulsby, E.J.L., 1965. Textbook of Veterinary Clinical Parasitology, Vol. 1., Helminths, (Blackwell Scientific, Oxford), 281–330

  • Stewart, T.B., Fox, M.C. and Wiles, S.E., 1997. Doramectin efficacy against gastrointestinal nematodes in pigs. Veterinary Parasitology, 66, 101–108

    Article  Google Scholar 

  • Swarnkar, C.P., Sanyal, P.K., Singh, D., Khan, F.A. and Bhagwan, P.S.K., 2001. Anthelmintic resistance on an organized sheep farm in India. Tropical Animal Health and Production, 33, 305–312

    Article  PubMed  CAS  Google Scholar 

  • Varady, M., Praslicka, J., Cobra, J. and Vesely, L., 1993. Multiple anthelmintic resistance of nematodes in imported goats. The Veterinary Record, 132, 387–388

    PubMed  CAS  Google Scholar 

  • Waller, P.J., 1994. The development of anthelmintic resistance in ruminants. Acta Tropica, 56, 233–243

    Article  PubMed  CAS  Google Scholar 

  • Waruiru, R.M., Ngotho, J.W., Mutune, M.N. and Munyua, W.K., 2003. Comparative efficacy of ivermectin, albendazole, levamisole and rafoxanide against gastrointestinal nematode infections in goats. Indian Journal of Animal Sciences, 73(2), 147–150

    Google Scholar 

  • Wirtherle, N., Schnieder, T. and Himmelstjerna, G.V.S., 2004. Prevalence of benzimidazole resistance on horse farms in Germany. The Veterinary Record, 154, 39–41

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Temperate Animal Husbandry Division, Indian Veterinary Research Institute, Nainital, Uttaranchal, India

    H. Ram, T. J. Rasool, A. K. Sharma, H. R. Meena & S. K. Singh

Authors
  1. H. Ram
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  2. T. J. Rasool
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  3. A. K. Sharma
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  4. H. R. Meena
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  5. S. K. Singh
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Correspondence to H. Ram.

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Ram, H., Rasool, T.J., Sharma, A.K. et al. Comparative Efficacy of Different Anthelmintics Against Fenbendazole-Resistant Nematodes of Pashmina Goats. Vet Res Commun 31, 719–723 (2007). https://doi.org/10.1007/s11259-007-0021-8

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  • DOI: https://doi.org/10.1007/s11259-007-0021-8

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