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Partial 3D gene sequences of Coxsackie viruses reveal interspecies exchanges

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Abstract

The 3D region of 46 clinical Coxsackievirus strains, primarily belonging to the human enterovirus B species (HEV-B), were analyzed using nucleotide distance matrices and phylogeny software. The conclusions from previously analyzed genomic regions (VP1—2A-2B-2C) of the aforementioned strains revealed that enteroviruses’ inheritance is being guided by gene adaptation among viruses of different serotypes. In this report the comparison of partial VP1 and 3D gene phylogenies presented an obvious incongruence. Moreover, the phylogeny of 3D sequences of the strains revealed an unexpected (and for the first time reported) homology among strains of different species. The observations of our study indicate that conversion events such as multiple mutations or recombination among strains and unknown donors may occur during the evolution of circulating strains, leading, probably, to viruses with altered genome and virulence.

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Acknowledgments

The authors would like to thank Prof. Glyn Stanway, Dr Francis Delpeyroux, Dr Marianna Combiescu, Dr G. Papageorgiou, and Prof. George Berensci for the kind provision of many CAV and CBV strains

The present work was co funded by the European Union (75%) and the Greek Ministry of Education (25%) under the framework of the Education and Initial Vocational Training Program “Pythagoras II”. Research project: “Molecular detection of enteroviruses in clinical samples and the environment. Implications for the public health .Code 52213.11”.

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Authors and Affiliations

  1. Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimioupolis, Athens, Greece

    Eugenia Bolanaki, Lukas Margaritis & Theodoros Katsorchis

  2. Virology Laboratory, Hellenic Pasteur Institute, 127, Vasilissis Sofias Ave, Athens, 115 21, Greece

    Eugenia Bolanaki

  3. Department of Biochemistry & Biotechnology, Microbiology—Virology Laboratory, University of Thessaly, 26 Ploutonos & Aeolou str., Larisa, 41221, Greece

    Christine Kottaridi, Panayotis Markoulatos & Zaharoula Kyriakopoulou

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  1. Eugenia Bolanaki
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  2. Christine Kottaridi
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Correspondence to Panayotis Markoulatos.

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Bolanaki, E., Kottaridi, C., Markoulatos, P. et al. Partial 3D gene sequences of Coxsackie viruses reveal interspecies exchanges. Virus Genes 35, 129–140 (2007). https://doi.org/10.1007/s11262-007-0083-2

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  • DOI: https://doi.org/10.1007/s11262-007-0083-2

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