Abstract
Kidney cells are the common host for JC virus (JCV) and BK virus (BKV). Reactivation of JCV and/or BKV in patients after organ transplantation, such as renal transplantation, may cause hemorrhagic cystitis and polyomavirus-associated nephropathy. Furthermore, JCV and BKV may be shed in the urine after reactivation in the kidney. Rearranged as well as archetypal non-coding control regions (NCCRs) of JCV and BKV have been frequently identified in human samples. In this study, three JC/BK recombined NCCR sequences were identified in the urine of a patient who had undergone renal transplantation. They were designated as JC–BK hybrids 1, 2, and 3. The three JC/BK recombinant NCCRs contain up-stream JCV as well as down-stream BKV sequences. Deletions of both JCV and BKV sequences were found in these recombined NCCRs. Recombination of DNA sequences between JCV and BKV may occur during co-infection due to the relatively high homology of the two viral genomes.
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Acknowledgments
The authors would like to thank Dr. Michael WY Chan from the National Chung Cheng University for his critical reading and English editing. This work was supported by research grants from the National Science Council, NSC99-2321-B-194-001 and Chung Shan Medical University Hospital, CSH-2009-A-009, Taiwan, ROC.
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Yu-Ching Liaw and Cheng-Hsu Chen contributed equally to this work.
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Liaw, YC., Chen, CH., Shu, KH. et al. Recombined sequences between the non-coding control regions of JC and BK viruses found in the urine of a renal transplantation patient. Virus Genes 45, 581–584 (2012). https://doi.org/10.1007/s11262-012-0815-9
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DOI: https://doi.org/10.1007/s11262-012-0815-9