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Current understanding of genomic DNA of porcine circovirus type 2

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Abstract

Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases in swine and is also described as the modulator of host immunity that exacerbates the clinical outcome of many bacterial and viral infections. To date, it has caused increasingly larger losses in the pig industry worldwide. The genomic DNA of PCV2 is predicted to contain 11 open reading frames (ORFs) and at least seven potential ORFs-encoding proteins larger than 5 kDa. Currently, however, only five virally encoded proteins (Rep, Rep′, Cap, ORF3, and ORF4 protein) have been identified in PCV2 replication. In the present review, we strive to discuss the current understanding of the genomic DNA of PCV2 with the purpose of providing insight into the scientific basis of the pathogenesis of PCV2 and the prevention of its infection.

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Acknowledgments

This review was supported in part by a grant from the National Natural Science Foundation of China (Project No. 30972186).

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The authors declare that they do not have any conflict of interests with respect to the research, authorship, and/or publication of this article.

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  1. College of Veterinary Medicine, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China

    Qi-zhuang Lv, Kang-kang Guo & Yan-ming Zhang

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Lv, Qz., Guo, Kk. & Zhang, Ym. Current understanding of genomic DNA of porcine circovirus type 2. Virus Genes 49, 1–10 (2014). https://doi.org/10.1007/s11262-014-1099-z

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