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Clinical Value of Image Fusion from MR and PET in Patients with Head and Neck Cancer

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Abstract

Purpose

This study aimed to evaluate the clinical value of image fusion from magnetic resonance (MR) combined with positron emission tomography (PET) imaging, using 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) in head and neck cancer.

Methods

Sixty-five consecutive patients underwent MR and FDG-PET scans before or after the treatment of known or suspected head and neck cancer. T1-weighted and T2-weighted images were first assessed by MR interpretation, and then, the fused images of T2-weighted images from MR and PET were evaluated in a blind manner. Diagnostic performance was compared.

Procedures

For initial staging, in 48 patients, malignant tumors were histologically confirmed in 45 patients. The interpretation sensitivities of MR alone and fused images for primary tumors were 98% and 100%, respectively. For lymph node metastasis, the sensitivity and specificity of both methods were 85% and 92%, respectively. Of 15 patients with suspected recurrence, ten patients had recurrent tumors, three patients developed second malignant tumors, and two patients had no recurrence. For these patients, the overall sensitivity of MR alone was 67%, whereas that of the fused images was 92%. Eight additional lesions were accurately diagnosed by image fusion only. In two patients with lymph node metastasis from unknown origin, the primary site was not detected in one patient, while tonsilar cancer was identified only by image fusion interpretation.

Conclusion

Image fusion from MR with PET might be useful in evaluating head and neck cancer, especially in suspected recurrent cases rather than in fresh cases.

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References

  1. Curtin HD, Ishwaran H, Mancuso AA, Dalley RW, Caudry DJ, McNeil BJ (1998) Comparison of CT and MR imaging in staging of neck metastases. Radiology 207:123–130

    CAS  PubMed  Google Scholar 

  2. King AD, Tse GM, Yuen EH et al (2004) Comparison of CT and MR imaging for the detection of extranodal neoplastic spread in metastatic neck nodes. Eur J Radiol 52:264–270

    Article  PubMed  Google Scholar 

  3. Kataoka M, Ueda H, Koyama T et al (2005) Contrast-enhanced volumetric interpolated breath-hold examination compared with spin-echo T1-weighted imaging of head and neck tumors. AJR Am J Roentgenol 184:313–319

    PubMed  Google Scholar 

  4. Hannah A, Scott AM, Tochon-Danguy H et al (2002) Evaluation of 18 F-fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer. Ann Surg 236:208–217

    Article  PubMed  Google Scholar 

  5. Kitagawa Y, Nishizawa S, Sano K et al (2003) Prospective comparison of 18F-FDG PET with conventional imaging modalities (MRI, CT, and 67Ga scintigraphy) in assessment of combined intraarterial chemotherapy and radiotherapy for head and neck carcinoma. J Nucl Med 44:198–206

    PubMed  Google Scholar 

  6. Ng SH, Yen TC, Chang JT et al (2006) Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol 24:4371–4376

    Article  PubMed  Google Scholar 

  7. Stokkel MP, Moons KG, ten Broek FW, van Rijk PP, Hordijk GJ (1999) 18F-fluorodeoxyglucose dual-head positron emission tomography as a procedure for detecting simultaneous primary tumors in cases of head and neck cancer. Cancer 86:2370–2377

    Article  CAS  PubMed  Google Scholar 

  8. Nishiyama Y, Yamamoto Y, Yokoe K et al (2005) FDG PET as a procedure for detecting simultaneous tumours in head and neck cancer patients. Nucl Med Commun 26:239–244

    Article  PubMed  Google Scholar 

  9. Schoeder H, Yeung HW, Gonen M, Kraus D, Larson SM (2004) Head and neck cancer: clinical usefulness and accuracy of PET/CT image fusion. Radiology 231:65–72

    Article  Google Scholar 

  10. Schwartz DL, Ford E, Rajendran J et al (2005) FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 61:129–136

    PubMed  Google Scholar 

  11. Jeong HS, Baek CH, Son YI et al (2007) Use of integrated 18F-FDG PET/CT to improve the accuracy of initial cervical nodal evaluation in patients with head and neck squamous cell carcinoma. Head Neck 29:203–210

    Article  PubMed  Google Scholar 

  12. Murakami R, Uozumi H, Hirai T et al (2007) Impact of FDG-PET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 68:377–382

    PubMed  Google Scholar 

  13. Nakamoto Y, Tatsumi M, Hammoud D, Cohade C, Osman MM, Wahl RL (2005) Normal FDG distribution patterns in the head and neck: PET/CT evaluation. Radiology 234:879–885

    Article  PubMed  Google Scholar 

  14. Wang D, Schultz CJ, Jursinic PA et al (2006) Initial experience of FDG-PET/CT guided IMRT of head-and-neck carcinoma. Int J Radiat Oncol Biol Phys 65:143–151

    PubMed  Google Scholar 

  15. Uematsu H, Sadato N, Yonekura Y et al (1998) Coregistration of FDG PET and MRI of the head and neck using normal distribution of FDG. J Nucl Med 39:2121–2127

    CAS  PubMed  Google Scholar 

  16. Somer EJ, Marsden PK, Benatar NA, Goodey J, O’Doherty MJ, Smith MA (2003) PET-MR image fusion in soft tissue sarcoma: accuracy, reliability and practicality of interactive point-based and automated mutual information techniques. Eur J Nucl Med Mol Imaging 30:54–62

    Article  PubMed  Google Scholar 

  17. CÃzek J, Herholz K, Vollmar S, Schrader R, Klein J, Heiss WD (2004) Fast and robust registration of PET and MR images of human brain. Neuroimage 22:434–442

    Article  Google Scholar 

  18. Borgwardt L, Højgaard L, Carstensen H et al (2005) Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. J Clin Oncol 23:3030–3037

    Article  PubMed  Google Scholar 

  19. Hamacher K, Coenen HH, Stoklin G (1986) Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27:235–238

    CAS  PubMed  Google Scholar 

  20. Kitano H, Magata Y, Tanaka A et al (2001) Performance assessment of O-18 water purifier. Ann Nucl Med 15:75–78

    Article  CAS  PubMed  Google Scholar 

  21. Sumi M, Sakihama N, Sumi T et al (2003) Discrimination of metastatic cervical lymph nodes with diffusion-weighted MR imaging in patients with head and neck cancer. AJNR Am J Neuroradiol 24:1627–1634

    PubMed  Google Scholar 

  22. Vandecaveye V, De Keyzer F, Nuyts S et al (2007) Detection of head and neck squamous cell carcinoma with diffusion weighted MRI after (chemo)radiotherapy: correlation between radiologic and histopathologic findings. Int J Radiat Oncol Biol Phys 67:960–971

    PubMed  Google Scholar 

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Acknowledgment

The authors would like to thank the staff members of the Radioisotope Ward in Kyoto University Hospital for their excellent technical support during the image acquisition.

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Authors and Affiliations

  1. Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara-cho, Sakyo-Ku, Kyoto, 606-8507, Japan

    Yuji Nakamoto, Ken Tamai, Tatsuya Higashi, Tadashi Hara, Tsuyoshi Suga, Takashi Koyama & Kaori Togashi

  2. Department of Diagnostic Imaging Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-Ku, Chiba, 263-8555, Japan

    Tsuneo Saga

Authors
  1. Yuji Nakamoto
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  2. Ken Tamai
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  3. Tsuneo Saga
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  4. Tatsuya Higashi
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  5. Tadashi Hara
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  6. Tsuyoshi Suga
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  7. Takashi Koyama
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  8. Kaori Togashi
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Corresponding author

Correspondence to Yuji Nakamoto.

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Nakamoto, Y., Tamai, K., Saga, T. et al. Clinical Value of Image Fusion from MR and PET in Patients with Head and Neck Cancer. Mol Imaging Biol 11, 46–53 (2009). https://doi.org/10.1007/s11307-008-0168-x

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  • DOI: https://doi.org/10.1007/s11307-008-0168-x

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