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Peritumoral Brain Edema in Meningiomas Depends on Aquaporin-4 Expression and Not on Tumor Grade, Tumor Volume, Cell Count, or Ki-67 Labeling Index

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Abstract

Purpose

The aim of this study was to investigate to which degree the peritumoral brain edema in patients with meningiomas depends on aquaporin-4 (AQP4) expression, tumor grade, tumor volume, Ki-67 expression, and cell count.

Procedures

Thirty-three patients (25 women, 8 men; mean age 56.6 ± 16.0 years) with an intracranial meningioma underwent a standardized magnetic resonance (MR) examination prior to surgical resection. Edema indices (EIs) and tumor volumes were measured on the MR images. Tumor grade was classified according to the World Health Organization, and the proliferation index was estimated on Ki-67 antigen-stained specimens. Tumor cell count was evaluated. Eighteen specimens were stained for AQP4 expressioon.

Results

Significant intergroup differences between AQP4 expression grades and EIs were observed (P = 0.03), and a positive correlation was detected between EIs and AQP4 expression grades (r = 0.54; P < 0.05). A ROC analysis with EI as a test variable revealed an AUC of 0.77 (95 % CI 0.55–0.99) for the prediction of a moderate-to-strong AQP4 expression. An EI ≥1.5 predicted a moderate-to-high AQP4 expression with a sensitivity of 77 % and a specificity of 60 %. EI values of 2.2 and 3.5 reached sensitivity/specificity values of 69/80 % and 54/100 %, respectively. The AQP4 expression did not show any significant correlations with tumor grading, tumor volume, Ki-67 expression, or cell count. Moreover, we observed no significant positive or negative correlations between the EI and tumor grading (P = 0.7), tumor volume (P = 0.19), Ki-67 index (P = 0.9), and cell count (P = 0.34).

Conclusion

Peritumoral brain edema in patients with meningiomas may depend on AQP4 expression grades and not on tumor grade, tumor volume, Ki-67 expression, and cell count. The amount of edema predicted AQP4 expressions with moderate-to-good sensitivity and specificity.

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Authors and Affiliations

  1. Department of Neuroradiology, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany

    Matthias Gawlitza, Stefan Schob & Karl-Titus Hoffmann

  2. Department of Dermatology, Martin Luther University Halle-Wittenberg, Halle, Germany

    Eckhard Fiedler

  3. Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany

    Alexey Surov

  4. Department of Radiology, Martin Luther University Halle-Wittenberg, Halle, Germany

    Alexey Surov

Authors
  1. Matthias Gawlitza
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  2. Eckhard Fiedler
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  3. Stefan Schob
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  4. Karl-Titus Hoffmann
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  5. Alexey Surov
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Corresponding author

Correspondence to Matthias Gawlitza.

Ethics declarations

This study was approved by institutional review board of Martin Luther University Halle-Wittenberg.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Gawlitza, M., Fiedler, E., Schob, S. et al. Peritumoral Brain Edema in Meningiomas Depends on Aquaporin-4 Expression and Not on Tumor Grade, Tumor Volume, Cell Count, or Ki-67 Labeling Index. Mol Imaging Biol 19, 298–304 (2017). https://doi.org/10.1007/s11307-016-1000-7

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  • DOI: https://doi.org/10.1007/s11307-016-1000-7

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