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Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS)

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Abstract

Obstructive sleep apnea syndrome (OSAS) is an often underestimated sleep disorder that has been associated with cardiovascular disease. OSAS is characterized by cycles of apnea and/or hypopnea during sleep caused by the collapse of the upper airways. Intermittent hypoxia deriving from the cycles of apnea/arousals (to retrieve the ventilation) plays a pivotal role in the pathogenesis of the disease. Obesity is the most frequent predisposing condition of OSAS. Recent evidence suggests that OSAS could be considered as a pro-atherosclerotic disease, independently of visceral fat amount. Oxidative stress, cardiovascular inflammation, endothelial dysfunction, and metabolic abnormalities in OSAS could accelerate atherogenesis. The present review is focused on the possible pathophysiological mediators which could favor atherosclerosis in OSAS.

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Acknowledgments

François Mach and Fabrizio Montecucco equally contributed as last authors to this work. This work was funded by EU FP7, Grant Number 201668, AtheroRemo and supported by a grant from the Swiss National Science Foundation to Dr. F. Mach (#310030-118245).

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  1. Division of Cardiology, Geneva University Hospital, Avenue de la Roseraie 64, 1205, Geneva, Switzerland

    Alessandra Quercioli

  2. Division of Cardiology, Foundation for Medical Researches, Geneva University Hospital, Avenue de la Roseraie 64, 1211, Geneva, Switzerland

    François Mach & Fabrizio Montecucco

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  1. Alessandra Quercioli
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  2. François Mach
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Correspondence to Fabrizio Montecucco.

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Quercioli, A., Mach, F. & Montecucco, F. Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS). Sleep Breath 14, 261–269 (2010). https://doi.org/10.1007/s11325-010-0338-3

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  • DOI: https://doi.org/10.1007/s11325-010-0338-3

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