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Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea

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Abstract

Purpose

The aim of our study was to analyze the effects of an antioxidant treatment on markers of oxidative and carbonyl stress in a rat model of obstructive sleep apnea.

Methods

Wistar rats were randomized into six groups—according to gender and intervention—sham, intermittent hypoxia, and intermittent hypoxia with treatment by vitamins C and E. Rats underwent tracheostomy. The tracheal cannula was closed for 12 s every minute for 1 h to simulate obstructive sleep apnea-related intermittent hypoxia. In the treatment group, rats received vitamin C and E 24 h prior to surgery.

Results

The intervention had a significant effect on advanced oxidation protein products (p = 0.008) and advanced glycation end products–specific fluorescence (p = 0.006) but no effect on malondialdehyde. Oxidation and glycation protein products were higher in intermittent hypoxia groups than in sham and in treated groups.

Conclusions

Antioxidants alleviate oxidative and carbonyl stress in an experimental model of obstructive sleep apnea. Future studies will show whether such treatment has any clinical value regarding cardiovascular complications of sleep apnea syndrome, preferably in patients with low compliance to continuous positive airway pressure.

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Conflicts of interest

None

Disclosure of financial support

This publication is the result of the project implementation: “TRANSMED 2” ITMS: 26240120030 supported by the Research and Development Operational Program funded by the ERDF.

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Authors and Affiliations

  1. Institute of Molecular Biomedicine, Comenius University, Sasinkova 4 811 08, Bratislava, Slovak Republic

    Peter Celec, Roman Buchta, Ivan Bartík, Roman Gardlík, Roland Pálffy & Július Hodosy

  2. Institute of Pathophysiology, Comenius University, Bratislava, Slovakia

    Peter Celec

  3. Department of Molecular Biology, Comenius University, Bratislava, Slovakia

    Peter Celec

  4. University Hospital, Bratislava, Slovakia

    Ingrid Jurkovičová, Imrich Mucska & Július Hodosy

  5. Institute of Physiology, Comenius University, Bratislava, Slovakia

    Július Hodosy

Authors
  1. Peter Celec
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  2. Ingrid Jurkovičová
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  3. Roman Buchta
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  4. Ivan Bartík
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  5. Roman Gardlík
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  6. Roland Pálffy
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  7. Imrich Mucska
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  8. Július Hodosy
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Corresponding author

Correspondence to Peter Celec.

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Celec, P., Jurkovičová, I., Buchta, R. et al. Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea. Sleep Breath 17, 867–871 (2013). https://doi.org/10.1007/s11325-012-0728-9

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  • DOI: https://doi.org/10.1007/s11325-012-0728-9

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