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Forces created by mandibular advancement devices in OSAS patients

A pilot study during sleep

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Abstract

Background

The aim of this study was to measure forces created by progressive mandibular advancement with an oral device, during natural sleep, in a sample of adult patients with obstructive sleep apnea syndrome (OSAS).

Methods

A pressure transducer system was placed on the acrylic arms of a two-piece oral appliance (Herbst type) used by nine moderate to severe OSAS patients, in addition to all captors routinely used for polysomnography. Strains on the left and right sides were collected, during stable sleep stages without arousal, for each step of 1 mm advancement.

Results

The mean force in this sample was 1.18 N/mm and showed an almost linear evolution. Measurements showed intra- and inter-individual variability.

Conclusion

The force values recorded in this study may explain the occlusal and skeletal side effects associated with long-term use of these oral appliances. They illustrate the influence of the extent of mandibular advancement, and indicate a possible dose-dependent effect.

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References

  1. American Sleep Disorders Association (1995) Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances. Sleep 18:511–513

    Google Scholar 

  2. Young T, Peppard PE, Gottieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165:1217–1239

    Article  PubMed  Google Scholar 

  3. Giles TL, Lasserson TJ, Smith BH, White J, Wright J, Cates CJ (2006) Continuous positive airways pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev 19(3):CD001106

    Google Scholar 

  4. Engleman HM, Martin SE, Douglas NJ (1994) Compliance with CPAP therapy in patients with the sleep apnoea/hypopnoea syndrome. Thorax 49(3):263–266

    Article  PubMed  CAS  Google Scholar 

  5. Weaver TE, Grunstein RR (2008) Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc 5:173–178

    Article  PubMed  Google Scholar 

  6. Haniffa M, Lasserson TJ, Smith I (2004) Interventions to improve compliance with continuous positive airway pressure for obstructive sleep apnoea. Cochrane Database Syst Rev 18(4):CD003531

    Google Scholar 

  7. Anandam A, Akinnusi M, Kufel T, Porhomayon J, El-Solh AA (2012) Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis. Sleep Breath Feb 29. doi:10.1111/j.1747-0285.2012.01402.x

  8. Sundaram S, Bridgman SA, Lim J, Lasserson TJ (2005) Surgery for obstructive sleep apnoea. Cochrane Database Syst Rev 19(4):CD001004

    Google Scholar 

  9. Pirklbauer K, Russmueller G, Stiebellehner L, Nell C, Sinko K, Millesi G, Klug C (2011) Maxillomandibular advancement for treatment of obstructive sleep apnea syndrome: a systematic review. J Oral Maxillofac Surg 69(6):165–176

    Article  Google Scholar 

  10. Gagnadoux F, Fleury B, Vielle B, Pételle B, Meslier N, N'Guyen XL, Trzepizur W, Racineux JL (2009) Titrated mandibular advancement versus positive airway pressure for sleep apnoea. Eur Respir J 34(4):914–920

    Article  PubMed  CAS  Google Scholar 

  11. Mehta A, Qian J, Petocz P, Darendeliler MA, Cistulli PA (2001) A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Am J Respir Crit Care Med 163:1457–1461

    Article  PubMed  CAS  Google Scholar 

  12. Marklund M, Stenlund H, Franklin KA (2004) Mandibular advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Chest 125(4):1270–1278

    Article  PubMed  Google Scholar 

  13. Lowe AA, Sjöholm TT, Ryan CF, Fleetham JA, Ferguson KA, Remmers JE (2000) Treatment, airway and compliance effects of a titrable oral appliance. Sleep 23:S172–S178

    PubMed  Google Scholar 

  14. Ryan CF, Love LL, Peat D, Fleetham JA, Lowe AA (1999) Mandibular advancement oral appliance therapy for obstructive sleep apnoea: effect on awake calibre of the velopharynx. Thorax 54:972–977

    Article  PubMed  CAS  Google Scholar 

  15. Kato J, Isono S, Tanaka A, Watanabe T, Araki D, Tanzawa H, Nishino T (2000) Dose-dependent effects on pharyngeal mechanics and nocturnal oxygenation in patients with sleep-disordered breathing. Chest 117:1065–1072

    Article  PubMed  CAS  Google Scholar 

  16. Walker-Engstrom ML, Ringqvist I, Vestling O, Wilhelmsson B, Tegelberg A (2003) A prospective randomized study comparing two different degrees of mandibular advancement with a dental appliance in treatment of severe obstructive sleep apnea. Sleep Breath 7(3):119–130

    Article  PubMed  Google Scholar 

  17. Aarab G, Lobbezoo F, Hamburger HL, Naeije M (2010) Effects of an oral appliance with different mandibular protrusion positions at a constant vertical dimension on obstructive sleep apnea. Clin Oral Investig 14(3):339–345

    Article  PubMed  Google Scholar 

  18. Pételle B, Vincent G, Gagnadoux F, Rakotonanahary D, Meyer B, Fleury B (2002) One-night mandibular advancement titration for obstructive sleep apnea syndrome: a pilot study. Am J Respir Crit Care Med 165(8):1150–1153

    Article  PubMed  Google Scholar 

  19. Tsuiki S, Hiyama S, Ono T, Imamura N, Ishiwata Y, Kuroda T et al (2001) Effects of a titratable oral appliance on supine airway size. Sleep 24:554–560

    PubMed  CAS  Google Scholar 

  20. Kyung SH, Park YC, Pae EK (2005) Obstructive sleep apnea patients with the oral appliance experience pharyngeal size and shape changes in three dimensions. Angle Orthod 75:15–22

    PubMed  Google Scholar 

  21. Zao, Liu, Gao (2008) Three-dimensional upper-airway changes associated with various amounts of mandibular advancement in awake apnea patients. Am J Orthod Dentofac Orthop 133:661–668

    Article  Google Scholar 

  22. Choi JK, Hur YK, Lee JM, Clark GT (2010) Effects of mandibular advancement on upper airway dimension and collapsibility in patients with obstructive sleep apnea using dynamic upper airway imaging during sleep. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109(5):712–719

    Article  PubMed  Google Scholar 

  23. Fleury B, Rakotonanahary D, Petelle B, Vincent G, Pelletier Fleury N, Meyer B, Lebeau B (2004) Mandibular advancement titration for obstructive sleep apnea: optimization of the procedure by combining clinical and oximetric parameters. Chest 125(5):1761–1767

    Article  PubMed  Google Scholar 

  24. Fleury B, Nguyen XL, Rakotonanahary D, Cohen-Levy J, Pételle B (2009) The set-up of obstructive sleep apnea treatment. Rev Pneumol Clin 65(4):214–218

    Article  PubMed  CAS  Google Scholar 

  25. Fritsch KM, Iseli A, Russi EW, Bloch KE (2001) Side effects of mandibular advancement devices for sleep apnea treatment. Am J Respir Crit Care Med 164(5):813–818

    Article  PubMed  CAS  Google Scholar 

  26. Marklund M, Franklin KA, Persson M (2001) Orthodontic side-effects of mandibular advancement devices during treatment of snoring and sleep apnoea. Eur J Orthod 23(2):135–144

    Article  PubMed  CAS  Google Scholar 

  27. Robertson CJ (2001) Dental and skeletal changes associated with long-term mandibular advancement. Sleep 24(5):531–537

    PubMed  CAS  Google Scholar 

  28. Rose EC, Staats R, Virchow C Jr, Jonas IE (2002) Occlusal and skeletal effects of an oral appliance in the treatment of obstructive sleep apnea. Chest 122(3):871–877

    Article  PubMed  Google Scholar 

  29. Robertson C, Herbison P, Harkness M (2003) Dental and occlusal changes during mandibular advancement splint therapy in sleep disordered patients. Eur J Orthod 25(4):371–376

    Article  PubMed  Google Scholar 

  30. Battagel JM, Kotecha B (2005) Dental side-effects of mandibular advancement splint wear in patients who snore. Clin Otolaryngol 30(2):149–156

    Article  PubMed  CAS  Google Scholar 

  31. Almeida FR, Lowe AA, Sung JO, Tsuiki S, Otsuka R (2006) Long-term sequellae of oral appliance therapy in obstructive sleep apnea patients: part 1. Cephalometric analysis. Am J Orthod Dentofac Orthop 129(2):195–204

    Article  Google Scholar 

  32. Almeida FR, Lowe AA, Otsuka R, Fastlicht S, Farbood M, Tsuiki S (2006) Long-term sequellae of oral appliance therapy in obstructive sleep apnea patients: part 2. Study-model analysis. Am J Orthod Dentofac Orthop 129(2):205–213

    Article  Google Scholar 

  33. Noro T, Tanne K, Sakuda M (1994) Orthodontic forces exerted by activators with varying construction bite heights. Am J Orthod Dentofac Orthop 2:169–179

    Article  Google Scholar 

  34. Witt E, Komposch G (1971) Intermaxilläre Kraftwirkung bimaxillärer Geräte. Fortschr Kieferorthop 32:345–352

    Article  PubMed  CAS  Google Scholar 

  35. Katsavrias EG, Halazonetis DJ (1999) Intermaxillary forces during activator treatment. Am J Orthod Dentofac Orthop 115(2):133–137

    Article  CAS  Google Scholar 

  36. Graber TM, Neumann (1985) Functional appliances. In: Graber TM, Swain BF (eds) Orthodontics, current principles and techniques. C.V. Mosby, St. Louis, pp 369–404

    Google Scholar 

  37. Amoric M (2008) Bielles de Herbst décolettées, intérêt et limites. Rev Orthop Dento Faciale 42:27–34

    Article  Google Scholar 

  38. Reschaffen A, Kales AA (1968) A manual of standardized terminology: techniques and scoring system for sleep stages of human subjects. Brain Information Service/Brain Research Institute, Los Angeles, p 204

    Google Scholar 

  39. Dauvilliers Y, Arnulf I, d’Ortho MP, Coste A, Ducluzeau P, Grillet Y, Jondeau G, Kessler R, Moncely L, Philip P, Philippe C, Weitzenblum E, Pepin JL (2010) Quelle evaluation préthérapeutique d’un patient avec SAHOS nouvellement diagnostiqué? Rev Mal Respir 27(3):124–136

    Article  Google Scholar 

  40. Reitan K (1967) Clinical and histologic observations on tooth movement during and after orthodontic treatment. Am J Orthod 53(10):721–745

    Article  PubMed  CAS  Google Scholar 

  41. Tuncer BB, Ozmeriç N, Tuncer C, Teoman I, Cakilci B, Yücel A, Alpar R, Baloş K (2005) Levels of interleukin-8 during tooth movement. Angle Orthod 75(4):631–636

    PubMed  Google Scholar 

  42. Perinetti G, Serra E, Paolantonio M, Bruè C, Meo SD, Filippi MR, Festa F, Spoto G (2005) Lactate dehydrogenase activity in human gingival crevicular fluid during orthodontic treatment: a controlled, short-term longitudinal study. J Periodontol 76(3):411–417

    Article  PubMed  CAS  Google Scholar 

  43. Batra P, Kharbanda O, Duggal R, Singh N, Parkash H (2006) Alkaline phosphatase activity in gingival crevicular fluid during canine retraction. Orthod Craniofac Res 9(1):44–51

    Article  PubMed  CAS  Google Scholar 

  44. Sugiyama Y, Yamaguchi M, Kanekawa M, Yoshii M, Nozoe T, Nogimura A, Kasai K (2003) The level of cathepsin B in gingival crevicular fluid during human orthodontic tooth movement. Eur J Orthod 25(1):71–76

    Article  PubMed  Google Scholar 

  45. Gibson JM, King GJ, Keeling SD (1992) Long-term orthodontic tooth movement response to short-term force in the rat. Angle Orthod 62(3):211–215

    PubMed  CAS  Google Scholar 

  46. Fransson AM, Tegelberg A, Leissner L, Wenneberg B, Isacsson G (2003) Effects of a mandibular protruding device on the sleep of patients with obstructive sleep apnea and snoring problems: a 2-year follow-up. Sleep Breath 7(3):131–141

    Article  PubMed  Google Scholar 

  47. Hoffstein V (2007) Review of oral appliances for treatment of sleep-disordered breathing. Sleep Breath 11(1):1–22

    Article  PubMed  Google Scholar 

  48. El-Solh AA, Moitheennazima B, Akinnusi ME, Churder PM, Lafornara AM (2011) Combined oral appliance and positive airway pressure therapy for obstructive sleep apnea: a pilot study. Sleep Breath 15(2):203–208

    Article  PubMed  Google Scholar 

  49. Gomes SG, Custodio W, Jufer JS, Del Bel CA, Garcia RC (2010) Mastication, EMG activity and occlusal contact area in subjects with different facial types. Cranio 28(4):274–279

    PubMed  Google Scholar 

  50. Custodio W, Gomes SG, Faot F, Garcia RC, Del Bel Cury AA (2011) Occlusal force, electromyographic activity of masticatory muscles and mandibular flexure of subjects with different facial types. J Appl Oral Sci 19(4):343–349

    Article  PubMed  Google Scholar 

  51. Farella M, Palla S, Gallo LM (2009) Time frequency analysis of rhythmic masticatory muscle activity. Muscle Nerve 39(6):828–836

    Article  PubMed  Google Scholar 

  52. Dutra KM, Pereira FJ Jr, Rompré PH, Huynh N, Flemming N, Lavigne GJ (2009) Oro-facial activities in sleep bruxism patients and in normal subjects: a controlled polygraphic and audio–video study. J Oral Rehab 36(2):86–92

    Article  CAS  Google Scholar 

  53. Dıraçoğlu D, Alptekin K, Cifter ED, Güçlü B, Karan A, Aksoy C (2011) Relationship between maximal bite force and tooth wear in bruxist and non-bruxist individuals. Arch Oral Biol 56(12):1569–1575

    Article  PubMed  Google Scholar 

  54. Jonke E (2011) Left/right asymmetries and open/closed differences of interdental forces in the mandible. Eur J Orthod 33(6):642–646

    Article  PubMed  Google Scholar 

  55. Cohen-Levy J, Cohen N (2011) Computerized analysis of occlusal contacts after lingual orthodontic treatment in adults. Int Orthod 9(4):410–431

    PubMed  Google Scholar 

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Acknowledgements

We thank Prof. Robert Garcia for his advice. We also thank Prof. Alain Lautrou for his critical comments on the manuscript and his expertise in functional therapy. Special thanks to Prof. Claude Lévy and Dr Max Ganem for their kind assistance with translation. This study was supported by grants from the Programme Hospitalier de Recherche Clinique (Angers, France), ANTADIR and the Etablissement Public, Chancellerie de Paris (both Paris, France).

Conflict of interest

Dr. Boris Pételle and Dr. Bernard Fleury are consultants for Orthosom, a society selling oral appliances in France. All others authors declare no conflict of interest in relation to this article.

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Correspondence to J. Cohen-Levy.

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Cohen-Levy, J., Pételle, B., Pinguet, J. et al. Forces created by mandibular advancement devices in OSAS patients. Sleep Breath 17, 781–789 (2013). https://doi.org/10.1007/s11325-012-0765-4

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  • DOI: https://doi.org/10.1007/s11325-012-0765-4

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