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Salivary markers of oxidative stress in patients with obstructive sleep apnea treated with continuous positive airway pressure

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Abstract

Purpose

Obstructive sleep apnea syndrome (OSAS) is characterized by elevated oxidative stress. Measurement of oxidative stress in saliva seems to be promising in long-term treatment monitoring of OSAS patients. In this study, our aim was to investigate whether short-term continuous positive airway pressure (CPAP) treatment would influence oxidative stress in saliva.

Methods

Patients with diagnosed OSAS (16 women, 28 men) underwent polysomnography during the first night and CPAP treatment during the second night. Saliva samples were taken in the evening and morning on both days. Markers of oxidative stress and antioxidant status were analyzed in saliva.

Results

Evening concentrations of the salivary thiobarbituric acid reacting substances (p < 0.001), advanced glycation end-products (p < 0.001), and advanced oxidation protein products (p < 0.01) were significantly lower than morning values during the diagnostic night. However, salivary concentrations of none of the oxidative stress markers were significantly influenced by the CPAP treatment. No changes in salivary antioxidant status after CPAP therapy were found.

Conclusion

Salivary markers of oxidative stress and antioxidant status do not change significantly after one night treatment with CPAP. On the contrary, after 1 month with CPAP therapy, reduced markers of oxidative stress were reported. Therefore, the future studies should be focused on finding the optimal sampling frequency to clarify the potential of saliva for the monitoring of OSAS treatment.

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Acknowledgments

This study was funded by the Slovak Ministry of Education, Science, Research and Sport—grant number VEGA 1/0674/12. We would like to thank the anonymous reviewers for their constructive approach.

Conflict of interest

No conflict of interest to declare.

Author information

Authors and Affiliations

  1. Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovak Republic

    L’ubomíra Tóthová, Július Hodosy & Peter Celec

  2. Institute of Physiology, Comenius University, Bratislava, Slovakia

    Július Hodosy

  3. Sleep Laboratory, University Hospital, Comenius University, Bratislava, Slovakia

    Imrich Mucska

  4. Institute of Pathophysiology, Comenius University, Bratislava, Slovakia

    Peter Celec

  5. Department of Molecular Biology, Comenius University, Bratislava, Slovakia

    Peter Celec

Authors
  1. L’ubomíra Tóthová
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  2. Július Hodosy
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  3. Imrich Mucska
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  4. Peter Celec
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Correspondence to Július Hodosy.

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Tóthová, L., Hodosy, J., Mucska, I. et al. Salivary markers of oxidative stress in patients with obstructive sleep apnea treated with continuous positive airway pressure. Sleep Breath 18, 563–570 (2014). https://doi.org/10.1007/s11325-013-0919-z

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  • DOI: https://doi.org/10.1007/s11325-013-0919-z

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