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Shorter sleep duration is associated with poorer glycemic control in type 2 diabetes patients with untreated sleep-disordered breathing

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

The purpose of this study is to explore the impact of sleep duration on glycemic control in type 2 diabetes patients with untreated sleep-disordered breathing (SDB).

Methods

Ninety type 2 diabetes patients participated in the study. SDB was diagnosed using an overnight in-home monitoring device (WatchPAT200). Sleep duration was recorded by wrist actigraphy for 7 days. Medical records were reviewed for hemoglobin A1c (HbA1c) values.

Results

Seventy-one patients (78.8 %) were diagnosed with SDB [apnea-hypopnea index (AHI) ≥ 5]. In patients with SDB, there was no significant relationship between AHI and glycemic control. In addition, oxygen desaturation index, minimum oxygen saturation, and time spent below oxygen saturation of 90 % were not significantly correlated with glycemic control. Sleep duration, however, was inversely correlated with HbA1c (r = −0.264, p 0.026). Multiple regression analysis adjusting for age, sex, body mass index, insulin use, diabetes duration, and AHI revealed that sleep duration was significantly associated with HbA1c (p = 0.005). Each hour reduction in sleep duration was associated with a 4.8 % increase in HbA1c of its original value (95 % CI 1.5–8.0).

Conclusion

In type 2 diabetes patients with untreated SDB, shorter sleep duration was independently associated with poorer glycemic control. Sleep duration optimization may lead to improved glycemic control in this population.

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Acknowledgments

The study received grant support from Mahidol University.

Conflict of interest

S.R. received speaker honoraria from Sanofi Aventis and research grant from Merck. All other authors disclosed no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Authors and Affiliations

  1. Section of Endocrinology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Ratchathewi, Bangkok, 10400, Thailand

    Nantaporn Siwasaranond, Hataikarn Nimitphong, Sunee Saetung, Boonsong Ongphiphadhanakul & Sirimon Reutrakul

  2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Naricha Chirakalwasan

  3. Excellence Center for Sleep Disorders, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

    Naricha Chirakalwasan

Authors
  1. Nantaporn Siwasaranond
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  2. Hataikarn Nimitphong
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  3. Sunee Saetung
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  4. Naricha Chirakalwasan
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  5. Boonsong Ongphiphadhanakul
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  6. Sirimon Reutrakul
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Corresponding author

Correspondence to Sirimon Reutrakul.

Additional information

N. S. and H. N. contributed equally to this manuscript.

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Siwasaranond, N., Nimitphong, H., Saetung, S. et al. Shorter sleep duration is associated with poorer glycemic control in type 2 diabetes patients with untreated sleep-disordered breathing. Sleep Breath 20, 569–574 (2016). https://doi.org/10.1007/s11325-015-1243-6

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  • DOI: https://doi.org/10.1007/s11325-015-1243-6

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