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TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women

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Abstract

High levels of inflammatory mediators are associated with reduced physical capabilities and muscle function in the elderly. Single nucleotide polymorphisms (SNPs) may affect the expression and synthesis of these molecules, thus influencing the intensity of the inflammatory response and susceptibility to certain diseases. Physical exercise may attenuate age-related chronic inflammation and improve physical performance. This study evaluated the interaction between the SNP rs1800629 in TNF-α, rs1800795 in IL6, and rs1800896 in IL10 and the effect of physical exercise on physical performance and inflammation in elderly women. There was a significant interaction between rs1800629 and the effect of exercise on physical performance and between the combined 3-SNP genotype and changes in physical performance in response to exercise. These SNPs did not influence the effect of exercise on inflammatory parameters. Elderly women with a combination of genotypes associated with an anti-inflammatory profile (low TNF-α and IL-6 production, high IL-10 production) showed better physical performance independent of exercise modality, evidence of an interactive influence of genetic and environmental factors on improving physical performance in elderly women.

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Acknowledgments

This study was financed by FAPEMIG, CNPq, and supported by the Pro-Rectory for Research of the UFMG. D.S. Pereira was a grant holder of the Coordination of Improvement of Upper Level Staff [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)] during his Ph.D.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências da Reabilitação, Departamento de Fisioterapia, Universidade Federal de Minas Gerais/UFMG, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil

    Daniele Sirineu Pereira, Bárbara Zille de Queiroz, Alexandra Miranda Assumpção, Diogo Carvalho Felício, Daniela Maria da Cruz dos Anjos, Danielle Aparecida Gomes Pereira & Leani Souza Máximo Pereira

  2. Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Elvis Cristian Cueva Mateo, Aline Silva Miranda, Natália Pessoa Rocha & Antonio Lucio Teixeira

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  1. Daniele Sirineu Pereira
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  2. Elvis Cristian Cueva Mateo
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  3. Bárbara Zille de Queiroz
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  7. Natália Pessoa Rocha
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  8. Daniela Maria da Cruz dos Anjos
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  9. Danielle Aparecida Gomes Pereira
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  10. Antonio Lucio Teixeira
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  11. Leani Souza Máximo Pereira
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Corresponding author

Correspondence to Leani Souza Máximo Pereira.

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Pereira, D.S., Mateo, E.C.C., de Queiroz, B.Z. et al. TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women. AGE 35, 2455–2463 (2013). https://doi.org/10.1007/s11357-013-9515-1

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  • DOI: https://doi.org/10.1007/s11357-013-9515-1

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