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Assembly and structure of protein phosphatase 2A

  • In Memoriam: Professor Ray Wu
  • Published:
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Abstract

Protein phosphatase 2A (PP2A) represents a conserved family of important protein serine/threonine phosphatases in species ranging from yeast to human. The PP2A core enzyme comprises a scaffold subunit and a catalytic subunit. The heterotrimeric PP2A holoenzyme consists of the core enzyme and a variable regulatory subunit. The catalytic subunit of PP2A is subject to reversible methylation, mediated by two conserved enzymes. Both the PP2A core and holoenzymes are regulated through interaction with a large number of cellular cofactors. Recent biochemical and structural investigation reveals critical insights into the assembly and function of the PP2A core enzyme as well as two families of holoenzyme. This review focuses on the molecular mechanisms revealed by these latest advances.

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  1. Center for Structural Biology, Department of Biological Sciences and Biotechnology, and School of Medicine, Tsinghua University, Beijing, 100084, China

    YiGong Shi

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Supported by NIH grant R01 CA123155 and Start-up Funds from Tsinghua University

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Shi, Y. Assembly and structure of protein phosphatase 2A. SCI CHINA SER C 52, 135–146 (2009). https://doi.org/10.1007/s11427-009-0018-3

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