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Studies in the Modulation of Experimental Autoimmune Encephalomyelitis

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Abstract

Experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, can be induced through inoculation with several different central nervous system (CNS) proteins or peptides. Modulation of EAE, resulting in either protection from EAE or enhancement of EAE, can also be accomplished through either vaccination or DNA immunization with molecular mimics of self-CNS proteins. Previously published data on this method of EAE modulation will be reviewed. New data is presented, which demonstrates that EAE can also be modulated through the administration of the β-(1,3)-d-glucan, curdlan. Dendritic cells stimulated by curdlan are involved in the differentiation of the interleukin-17 producing subset of CD4+ T cells that are recognized effector cells in EAE. Using two different systems to study the effects of curdlan on EAE, it was found that curdlan increased the incidence of EAE and/or the severity of the disease course.

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Acknowledgment

We wish to thank Nikki J. Kirkman, BS, Faris Hasanovic, BS, Daniel J. Doty, and Krystal D. Porter, BS, for the excellent technical assistance. We wish to acknowledge Kathleen Borick for the outstanding preparation of the manuscript.

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Authors and Affiliations

  1. Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT, 84132, USA

    Jane E. Libbey & Robert S. Fujinami

  2. Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71130, USA

    Ikuo Tsunoda

Authors
  1. Jane E. Libbey
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  2. Ikuo Tsunoda
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  3. Robert S. Fujinami
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Corresponding author

Correspondence to Robert S. Fujinami.

Additional information

This work was supported by NIH grant 1P01AI058105.

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Libbey, J.E., Tsunoda, I. & Fujinami, R.S. Studies in the Modulation of Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol 5, 168–175 (2010). https://doi.org/10.1007/s11481-010-9215-x

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  • DOI: https://doi.org/10.1007/s11481-010-9215-x

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