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Minimizing the blood velocity differences between phase-contrast magnetic resonance imaging and computational fluid dynamics simulation in cerebral arteries and aneurysms

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Abstract

The integration of phase-contrast magnetic resonance images (PC-MRI) and computational fluid dynamics (CFD) is a way to obtain detailed information of patient-specific hemodynamics. This study proposes a novel strategy for imposing a pressure condition on the outlet boundary (called the outlet pressure) in CFD to minimize velocity differences between the PC-MRI measurement and the CFD simulation, and to investigate the effects of outlet pressure on the numerical solution. The investigation involved ten patient-specific aneurysms reconstructed from a digital subtraction angiography image, specifically on aneurysms located at the bifurcation region. To evaluate the effects of imposing the outlet pressure, three different approaches were used, namely: a pressure-fixed (P-fixed) approach; a flow rate control (Q-control) approach; and a velocity-field-optimized (V-optimized) approach. Numerical investigations show that the highest reduction in velocity difference always occurs in the V-optimized approach, where the mean of velocity difference (normalized by inlet velocity) is 19.3%. Additionally, the highest velocity differences appear near to the wall and vessel bifurcation for 60% of the patients, resulting in differences in wall shear stress. These findings provide a new methodology for PC-MRI integrated CFD simulation and are useful for understanding the evaluation of velocity difference between the PC-MRI and CFD.

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Acknowledgements

This work was supported in part by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (No. 23650261) and the Ministry of Education, Culture, Sports, Science and Technology project, “Creating Hybrid Organs of the Future” at Osaka University.

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Authors and Affiliations

  1. Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, 560-8531, Japan

    Mohd Azrul Hisham Mohd Adib, Satoshi Ii & Shigeo Wada

  2. Department of Radiology, Graduate School of Medicine, Osaka University, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yoshiyuki Watanabe

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  1. Mohd Azrul Hisham Mohd Adib
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  2. Satoshi Ii
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  4. Shigeo Wada
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Correspondence to Mohd Azrul Hisham Mohd Adib or Shigeo Wada.

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Mohd Adib, M.A.H., Ii, S., Watanabe, Y. et al. Minimizing the blood velocity differences between phase-contrast magnetic resonance imaging and computational fluid dynamics simulation in cerebral arteries and aneurysms. Med Biol Eng Comput 55, 1605–1619 (2017). https://doi.org/10.1007/s11517-017-1617-y

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  • DOI: https://doi.org/10.1007/s11517-017-1617-y

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