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A machine learning framework involving EEG-based functional connectivity to diagnose major depressive disorder (MDD)

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Abstract

Major depressive disorder (MDD), a debilitating mental illness, could cause functional disabilities and could become a social problem. An accurate and early diagnosis for depression could become challenging. This paper proposed a machine learning framework involving EEG-derived synchronization likelihood (SL) features as input data for automatic diagnosis of MDD. It was hypothesized that EEG-based SL features could discriminate MDD patients and healthy controls with an acceptable accuracy better than measures such as interhemispheric coherence and mutual information. In this work, classification models such as support vector machine (SVM), logistic regression (LR) and Naïve Bayesian (NB) were employed to model relationship between the EEG features and the study groups (MDD patient and healthy controls) and ultimately achieved discrimination of study participants. The results indicated that the classification rates were better than chance. More specifically, the study resulted into SVM classification accuracy = 98%, sensitivity = 99.9%, specificity = 95% and f-measure = 0.97; LR classification accuracy = 91.7%, sensitivity = 86.66%, specificity = 96.6% and f-measure = 0.90; NB classification accuracy = 93.6%, sensitivity = 100%, specificity = 87.9% and f-measure = 0.95. In conclusion, SL could be a promising method for diagnosing depression. The findings could be generalized to develop a robust CAD-based tool that may help for clinical purposes.

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Acknowledgement

This research work was supported by HiCoE research fund, Grant Number (0153CA-005), Ministry of Higher Education (MoHE), Malaysia.

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    Authors and Affiliations

    1. Center for Intelligent Signal and Imaging Research, Electrical and Electronic Engineering Department, Universiti Teknologi PETRONAS, 32610, Seri Iskandar, Malaysia

      Wajid Mumtaz, Syed Saad Azhar Ali & Aamir Saeed Malik

    2. Department of Psychiatry, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

      Mohd Azhar Mohd Yasin

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    1. Wajid Mumtaz
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    Correspondence to Aamir Saeed Malik.

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    Mumtaz, W., Ali, S.S.A., Yasin, M.A.M. et al. A machine learning framework involving EEG-based functional connectivity to diagnose major depressive disorder (MDD). Med Biol Eng Comput 56, 233–246 (2018). https://doi.org/10.1007/s11517-017-1685-z

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