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Costimulatory molecule B7-H1 on the immune escape of bladder cancer and its clinical significance

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Summary

B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in tumor immune escape by inducing T-cell apoptosis. In order to investigate the relationship between B7-H1 and immune escape of bladder cancer, B7-H1 expression in 50 cases of bladder cancer was detected by using immunohistochemical method. Survival curves were constructed using the Kaplan-Meier method and independent prognostic factors were evaluated using the Cox regression model. Our results showed that the positive rate of B7-H1 immunostaining in normal bladder tissue and bladder cancer was 0 and 72% respectively. The expression of B7-H1 was strongly associated with the pathological grade, clinical stage and recurrence (P<0.05). The survival rate was significantly lower in patients with B7-H1 positive group than in those with B7-H1 negative group and multi-variable analysis revealed that B7-H1 could be regarded as an independent factor in evaluating the prognosis of bladder cancer. It is concluded that the expression of B7-H1 is strongly associated with neoplastic progression and prognosis of bladder cancer. The manipulation of B7-H1 may become a beneficial target for immunotherapy in human bladder cancer.

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Authors and Affiliations

  1. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yonghua Wang  (王永华), Qianyuan Zhuang  (庄乾元), Siwei Zhou  (周四维), Zhiquan Hu  (胡志全) & Ruzhu Lan  (兰儒竹)

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  1. Yonghua Wang  (王永华)
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  2. Qianyuan Zhuang  (庄乾元)
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  3. Siwei Zhou  (周四维)
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  4. Zhiquan Hu  (胡志全)
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  5. Ruzhu Lan  (兰儒竹)
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Corresponding author

Correspondence to Yonghua Wang  (王永华).

Additional information

This project was supported by a grant from Hubei Provincial Science and Technology Key Program Foundation of China (No. 2007AA402C60).

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Wang, Y., Zhuang, Q., Zhou, S. et al. Costimulatory molecule B7-H1 on the immune escape of bladder cancer and its clinical significance. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 77–79 (2009). https://doi.org/10.1007/s11596-009-0116-2

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  • DOI: https://doi.org/10.1007/s11596-009-0116-2

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