Summary
Surgical excision and postoperative radiotherapy are widely accepted therapeutic modalities for sinonasal teratocarcinosarcoma (SNTCS). Previous studies have shown that intensity-modulated radiation therapy (IMRT) is safe and effective for the treatment of some sinonasal malignancies. We hypothesize that use of IMRT for SNTCS may result in clinical benefits. We report here two cases of SNTCS that were treated by IMRT. One patient was given extensive IMRT involving elective neck irradiation. Follow-up examinations revealed no recurrence and metastasis 3.5 years after IMRT. Another patient simultaneously suffered from multiple systematical diseases and was administered involved-field radiotherapy. He was found to have a marginal recurrence during the follow up and eventually died 8 months after disease diagnosis. It was suggested in this study that appropriate use of IMRT for the treatment of SNTCS may achieve excellent local control.
Similar content being viewed by others
References
Wei S, Carroll W, Lazenby A, et al. Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome. Ann diagn pathol, 2008,12(6): 415–425
Budrukkar A, Agarwal JP, Kane S, et al. Management and clinical outcome of sinonasal teratocarcinosarcoma: single institution experience. J laryngol otol, 2010,124(7): 739–743
Smith SL, Hessel AC, Luna MA, et al. Sinonasal teratocarcinosarcoma of the head and neck: a report of 10 patients treated at a single institution and comparison with reported series. Arch otolaryngol head & neck surg, 2008,134(6):592–595
Heffner DK, Hyams VJ. Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. Cancer, 1984,53(10):2140–2154
Sharma HS, Abdullah JM, Othman NH, et al. Teratocarcinosarcoma of the nasal cavity and ethmoid. J laryngolotol, 1998,112(7): 682–686
Takasaki K, Sakihama N, Takahashi H. A case with sinonasal teratocarcinosarcoma in the nasal cavity and ethmoid sinus. Eur Arch Otorhinolaryngol, 2006,263(6): 586–591
Parsons JT, Mendenhall WM, Mancuso AA, et al. Malignant tumors of the nasal cavity and ethmoid and sphenoid sinuses. Int J Radiat Oncol Biol Phys, 1988,14(1): 11–22
Daly ME, Chen AM, Bucci MK, et al. Intensitymodulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys, 2007,67(1):151–157
Lai SZ, Li WF, Chen L, et al. How does intensitymodulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys, 2011,80(3):661–668
Saarilahti K, Kouri M, Collan J, et al. Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function. Radiother Oncol, 2005,74(3):251–258
Madani I, Bonte K, Vakaet L, et al. Intensity-modulated radiotherapy for sinonasal tumors: Ghent University Hospital update. Int J Radiat Oncol Biol Phys, 2009,73(2):424–432
Shanmugaratnam K, Kunaratnam N, Chia KB, et al. Teratoid carcinosarcoma of the paranasal sinuses. Pathology, 1983,15(4):413–419
Carrizo F, Pineda-Daboin K, Neto AG, et al. Pharyngeal teratocarcinosarcoma: review of the literature and report of two cases. Ann diagn pathol, 2006,10(6):339–342
Rotenberg B, El-Hakim H, Lodha A, et al. Nasopharyngeal teratocarcinosarcoma. Int J Pediatr Otorhinolaryngol, 2002,62(2):159–164
Endo H, Hirose T, Kuwamura KI, et al. Case report: Sinonasal teratocarcinosarcoma. Pathol Intern, 2001,51(2): 107–112
Ogawa T, Ikeda K, Watanabe M, et al. A case report of sinonasal teratocarcinosarcoma. Tohoku J Exp Med, 2000, 190(1):51–59
Chao KK, Eng TY, Barnes J, et al. Sinonasal teratocarcinosarcoma. Am J Clin Oncol, 2004,27(1):29–32
Pai SA, Naresh KN, Masih K, et al. Teratocarcinosarcoma of the paranasal sinuses: a clinicopathologic and immunohistochemical study. Human pathology, 1998, 29(7):718–722
Batsakis JG, el-Naggar AK, Luna MA. Teratomas of the head and neck with emphasis on malignancy. Ann Otol Rhinol Laryngol, 1995,104(6):496–500
Duthoy W, Boterberg T, Claus F, et al. Postoperative intensity-modulated radiotherapy in sinonasal carcinoma: clinical results in 39 patients. Cancer, 2005,104(1):71–82
Claus F, Mijnheer B, Rasch C, et al. Report of a study on IMRT planning strategies for ethmoid sinus cancer. Strahlenther Onkol, 2002,178(10):572–576
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Peng, G., Ke, Y., Wang, T. et al. Intensity-modulated radiotherapy for sinonasal teratocarcinosarcoma. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 857–860 (2011). https://doi.org/10.1007/s11596-011-0691-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11596-011-0691-x