Abstract
The histopathological features of the middle cerebral artery (MCA) and superficial temporal artery (STA) from moyamoya disease (MMD) and their relationships with gender, age, angiography stage were explored. The causes and the clinical significance of vasculopathy of STA were also discussed. The clinical data and specimens of MCA and STA from 30 MMD patients were collected. Twelve samples of MCA and STA from non-MMD patients served as control group. Histopathological examination was then performed by measuring the thickness of intima and media, and statistical analysis was conducted. The MCA and STA specimens from MMD group had apparently thicker intima and thinner media than those from the control group. There was no significant pathological difference between the hemorrhage group and non-hemorrhage group, and between the males and females in MMD patients. Neither the age nor the digital subtraction angiography (DSA) stage was correlated with the thickness of intima in MCA and STA. MMD is a systemic vascular disease involving both intracranial and extracranial vessels. Preoperative external carotid arteriography, especially super-selective arteriography of the STA, benefits the selection of donor vessel.
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Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis). Neurol Med Chir, 2012,52(5):245–266
Kuroda S, Houkin K. Moyamoya disease: current concepts and future perspectives. Lancet Neurol, 2008,7(11):1056–1066
Takagi Y, Kikuta K, Nozaki K, et al. Histological features of middle cerebral arteries from patients treated for moyamoya disease. Neurol Med Chir, 2007,47(1):1–4
Aoyagi M, Fukai N, Yamamoto M, et al. Development of intimal thickening in superficial temporal arteries in patients with moyamoya disease. Clin Neurol Neurosurg, 1997,99(Suppl 2):S213–S217
Hosoda Y, Ikeda E, Hirose S. Histopathological studies on spontaneous occlusion of the circle of Willis (cerebrovascular moyamoya disease). Clin Neurol Neurosurg, 1997,99(Suppl 2):S203–S208
Aoyagi M, Fukai N, Yamamoto M, et al. Early development of intimal thickening in superficial temporal arteries in patients with moyamoya disease. Stroke, 1996,27(10):1750–1754
Jansen JN, Donker AJ, Luth WJ, et al. Moyamoya disease associated with renovascular hypertension. Neuropediatrics, 1990,21(1):44–47
Ikeda E. Systemic vascular changes in spontaneous occlusion of the circle of Willis. Stroke, 1991,22(11):1358–1362
Togao O, Mihara F, Yoshiura T, et al. Prevalence of stenoocclusive lesions in the renal and abdominal arteries in moyamoya disease. AJR Am J Roentgenol, 2004,183(1):119–122
Yamada I, Himeno Y, Matsushima Y, et al. Renal artery lesions in patients with moyamoya disease: angiographic findings. Stroke, 2000,31(3):733–737
Kronenburg A, Braun KP, van der Zwan A, et al. Recent advances in moyamoya disease: pathophysiology and treatment. Curr Neurol Neurosci Rep, 2014,14(1):423
Liu W, Morito D, Takashima S, et al. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PloS One, 2011,6(7):e22542
Lin R, Xie Z, Zhang J, et al. Clinical and immunopathological features of moyamoya disease. PloS One, 2012,7(4):e36386
Yamamoto M, Aoyagi M, Fukai N, et al. Increase in prostaglandin E(2) production by interleukin-1beta in arterial smooth muscle cells derived from patients with moyamoya disease. Circ Res, 1999,85(10):912–918
Zhang J, Xiong Z, Wang S, et al. Cyclooxygenase-2 and prostaglandin e2 are associated with middle cerebral artery occlusion and hemorrhage in patients with moyamoya disease. Curr Neurovasc Res, 2016,13(1):68–74
Li Z, Zhou P, Xiong Z, et al. Perfusion-weighted magnetic resonance imaging used in assessing hemodynamics following superficial temporal artery-middle cerebral artery bypass in patients with moyamoya disease. Cerebrovasc Dis, 2013,35(5):455–460
Katsuta T, Abe H, Miki K, et al. Reversible occlusion of donor vessel caused by mouth opening after superficial temporal artery-middle cerebral artery anastomosis in adult moyamoya patients. J Neurosurg, 2015,123(3):670–675
Zhu F, Zhang Y, Higurashi M, et al. Haemodynamic analysis of vessel remodelling in STA-MCA bypass for moyamoya disease and its impact on bypass patency. J Biomech, 2014,47(8):1800–1805
Kadri PA, Krisht AF, Gandhi GK. An anatomic mathematical measurement to find an adequate recipient M4 branch for superficial temporal artery to middle cerebral artery bypass surgery. Neurosurgery, 2007,61(3 Suppl):74–78
Charbel FT, Meglio G, Amin-Hanjani S. Superficial temporal artery-to-middle cerebral artery bypass. Neurosurgery, 2005,56(1 Suppl):186–190
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This project was supported by the key project of the Natural Science Foundation of Hubei Province of China (No. ZRZ2014000254) and the National Natural Science Foundation of China (No. 81571146).
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Sun, Sj., Zhang, Jj., Li, Zw. et al. Histopathological features of middle cerebral artery and superficial temporal artery from patients with moyamoya disease and enlightenments on clinical treatment. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 871–875 (2016). https://doi.org/10.1007/s11596-016-1677-5
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DOI: https://doi.org/10.1007/s11596-016-1677-5