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[18F]FDG-PET/CT in patients affected by retroperitoneal fibrosis: a bicentric experience

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Abstract

Purpose

The aim of our study was to assess the feasibility and usefulness of 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography computed tomography ([18F]FDG-PET/CT) in patients affected by retroperitoneal fibrosis.

Materials and methods

We retrospectively evaluated 25 patients studied in two centers: 18 underwent [18F]FDG-PET/CT as initial evaluation, three during follow-up, three during steroid therapy, and one to re-evaluate the disease. Among the group who underwent initial evaluation, ten underwent a second [18F]FDG-PET/CT after steroid therapy.

Results

[18F]FDG-PET/CT was positive in 18 patients and negative in seven. Among the ten patients who underwent a second study after steroid therapy, six showed complete metabolic response, three partial response, and one no significant maximum standardized uptake value (SUVmax) reduction.

Conclusion

Our preliminary results show that [18F]FDG-PET/CT is feasible and suitable for evaluating retroperitoneal fibrosis and is useful in assessing therapy response. Larger studies are desirable to confirm these findings and to determine the appropriate position of [18F]FDG-PET/CT in the diagnostic flow chart for this disease.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy

    Francesco Bertagna, Giovanni Bosio, Federica Motta & Raffaele Giubbini

  2. Nuclear Medicine, Catholic University of Sacred Heart, Rome, Italy

    Giorgio Treglia, Lucia Leccisotti & Alessandro Giordano

Authors
  1. Francesco Bertagna
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  2. Giorgio Treglia
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  3. Lucia Leccisotti
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  4. Giovanni Bosio
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  5. Federica Motta
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  6. Alessandro Giordano
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  7. Raffaele Giubbini
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Correspondence to Francesco Bertagna.

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Bertagna, F., Treglia, G., Leccisotti, L. et al. [18F]FDG-PET/CT in patients affected by retroperitoneal fibrosis: a bicentric experience. Jpn J Radiol 30, 415–421 (2012). https://doi.org/10.1007/s11604-012-0066-7

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  • DOI: https://doi.org/10.1007/s11604-012-0066-7

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