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Frontal Atrophy and Attention Deficits in Older Adults with a History of Elevated Depressive Symptoms

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Abstract

Studies of older adults with depressive disorders indicate greater cognitive deficits and brain alterations than would be expected for their age. There is some evidence that these findings are present after a single episode of depression, but this work has been cross-sectional in nature. We investigated both cross-sectional and longitudinal associations between a history of elevated depressive symptoms (HDS), frontal lobe volumes, and cognitive performance within the context of normal age-related changes over time in the Baltimore Longitudinal Study of Aging. After controlling for age, HDS was associated with smaller total frontal gray matter volumes and with smaller regional volumes in the cingulate gyrus and orbitofrontal cortex. Men, but not women, with HDS showed deficits in auditory attention span at older ages. Results confirm previous reports that even a single episode of depression is associated with adverse outcomes in older adults but suggest that HDS does not affect longitudinal trajectories of cognitive and brain volume change.

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References

  • Alexopoulos, G. S. (2002). Frontostriatal and limbic dysfunction in late-life depression. Am J Geriatr Psychiatry, 10(6), 687–695.

    PubMed  Google Scholar 

  • Alexopoulos, G. S., Meyers, B. S., Young, R. C., Kalayam, B., Kakuma, T., Gabrielle, M., et al. (2000). Executive dysfunction and long-term outcomes of geriatric depression. Arch Gen Psychiatry, 57(3), 285–290.

    Article  CAS  PubMed  Google Scholar 

  • Alexopoulos, G. S., Young, R. C., & Shindledecker, R. D. (1992). Brain computed tomography findings in geriatric depression and primary degenerative dementia. Biol Psychiatry, 31(6), 591–599.

    Article  CAS  PubMed  Google Scholar 

  • Ballmaier, M., Toga, A. W., Blanton, R. E., Sowell, E. R., Lavretsky, H., Peterson, J., et al. (2004). Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry, 161(1), 99–108.

    Article  PubMed  Google Scholar 

  • Baune, B. T., Suslow, T., Arolt, V., & Berger, K. (2007). The relationship between psychological dimensions of depressive symptoms and cognitive functioning in the elderly — the MEMOcStudy. J Psychiatr Res, 41(3–4), 247–254.

    Article  PubMed  Google Scholar 

  • Baune, B. T., Suslow, T., Engelien, A., Arolt, V., & Berger, K. (2006). The association between depressive mood and cognitive performance in an elderly general population — the MEMO Study. Dement Geriatr Cogn Disord, 22(2), 142–149.

    Article  PubMed  Google Scholar 

  • Beason-Held, L. L., Kraut, M. A., & Resnick, S. M. (2008a). i. Longitudinal changes in aging brain function. Neurobiol Aging, 29(4), 483–496.

    CAS  Google Scholar 

  • Beason-Held, L. L., Kraut, M. A., & Resnick, S. M. (2008b). II. Temporal patterns of longitudinal change in aging brain function. Neurobiol Aging, 29(4), 497–513.

    CAS  Google Scholar 

  • Beats, B. C., Sahakian, B. J., & Levy, R. (1996). Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med, 26(3), 591–603.

    Article  CAS  PubMed  Google Scholar 

  • Beekman, A. T., Deeg, D. J., Van Limbeek, J., Braam, A. W., De Vries, M. Z., & Van Tilburg, W. (1997). Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): results from a community-based sample of older subjects in The Netherlands. Psychol Med, 27(1), 231–235.

    Article  CAS  PubMed  Google Scholar 

  • Beekman, A. T., Kriegsman, D. M., Deeg, D. J., & van Tilburg, W. (1995). The association of physical health and depressive symptoms in the older population: age and sex differences. Soc Psychiatry Psychiatr Epidemiol, 30(1), 32–38.

    Article  CAS  PubMed  Google Scholar 

  • Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S., & Dolan, R. J. (1993). Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychol Med, 23(3), 579–590.

    Article  CAS  PubMed  Google Scholar 

  • Bench, C. J., Friston, K. J., Brown, R. G., Scott, L. C., Frackowiak, R. S., & Dolan, R. J. (1992). The anatomy of melancholia—focal abnormalities of cerebral blood flow in major depression. Psychol Med, 22(3), 607–615.

    Article  CAS  PubMed  Google Scholar 

  • Benton, A. L. (1968). Differential behavioral effects in frontal lobe disease. Neuropsychologia, 6(1), 53–60.

    Article  Google Scholar 

  • Blessed, G., & Wilson, I. D. (1982). The contemporary natural history of mental disorder in old age. Br J Psychiatry, 141, 59–67.

    Article  CAS  PubMed  Google Scholar 

  • Botteron, K. N., Raichle, M. E., Drevets, W. C., Heath, A. C., & Todd, R. D. (2002). Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry, 51(4), 342–344.

    Article  PubMed  Google Scholar 

  • Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., et al. (2002). Reduced volume of orbitofrontal cortex in major depression. Biol Psychiatry, 51(4), 273–279.

    Article  PubMed  Google Scholar 

  • Bremner, J. D., Vythilingam, M., Vermetten, E., Vaccarino, V., & Charney, D. S. (2004). Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression. Am J Psychiatry, 161(4), 637–645.

    Article  PubMed  Google Scholar 

  • Butters, M. A., Whyte, E. M., Nebes, R. D., Begley, A. E., Dew, M. A., Mulsant, B. H., et al. (2004). The nature and determinants of neuropsychological functioning in late-life depression. Arch Gen Psychiatry, 61(6), 587–595.

    Article  PubMed  Google Scholar 

  • Castaneda, A. E., Tuulio-Henriksson, A., Marttunen, M., Suvisaari, J., & Lonnqvist, J. (2008). A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults. J Affect Disord, 106(1–2), 1–27.

    Article  PubMed  Google Scholar 

  • Chodosh, J., Kado, D. M., Seeman, T. E., & Karlamangla, A. S. (2007). Depressive symptoms as a predictor of cognitive decline: MacArthur Studies of Successful Aging. Am J Geriatr Psychiatry, 15(5), 406–415.

    Article  PubMed  Google Scholar 

  • Dal Forno, G., Palermo, M. T., Donohue, J. E., Karagiozis, H., Zonderman, A. B., & Kawas, C. H. (2005). Depressive symptoms, sex, and risk for Alzheimer’s disease. Ann Neurol, 57(3), 381–387.

    Article  PubMed  Google Scholar 

  • de Asis, J. M., Stern, E., Alexopoulos, G. S., Pan, H., Van Gorp, W., Blumberg, H., et al. (2001). Hippocampal and anterior cingulate activation deficits in patients with geriatric depression. Am J Psychiatry, 158(8), 1321–1323.

    Article  PubMed  Google Scholar 

  • DeFries, J. C., Vandenberg, S. G., McClearn, G. E., Kuse, A. R., Wilson, J. R., Ashton, G. C., et al. (1974). Near identity of cognitive structure in two ethnic groups. Science, 183(122), 338–339.

    Article  CAS  PubMed  Google Scholar 

  • Delis, D., Kramer, J., Kaplan, E., & Ober, B. (1987). California Verbal Learning Test: Adult version. San Antonio, TX: The Psychological Corporation.

    Google Scholar 

  • Dolan, R. J., Bench, C. J., Brown, R. G., Scott, L. C., Friston, K. J., & Frackowiak, R. S. (1992). Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment. J Neurol Neurosurg Psychiatry, 55(9), 768–773.

    Article  CAS  PubMed  Google Scholar 

  • Dotson, V. M., Davatzikos, C., Kraut, M. A., & Resnick, S. M. (2009). Depressive Symptoms and Brain Volumes in Older Adults: A Longitudinal MRI Study. Journal of Psychiatry and Neuroscience, 34(5), 367–375.

    PubMed  Google Scholar 

  • Dotson, V. M., Resnick, S. M., & Zonderman, A. B. (2008). Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults. Am J Geriatr Psychiatry, 16(4), 318–330.

    Article  PubMed  Google Scholar 

  • Drevets, W. C. (2000). Neuroimaging studies of mood disorders. Biol Psychiatry, 48(8), 813–829.

    Article  CAS  PubMed  Google Scholar 

  • Drevets, W. C., Price, J. L., Simpson, J. R., Jr., Todd, R. D., Reich, T., Vannier, M., et al. (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386(6627), 824–827.

    Article  CAS  PubMed  Google Scholar 

  • Driscoll, I., Resnick, S. M., Troncoso, J. C., An, Y., O’Brien, R., & Zonderman, A. B. (2006). Impact of Alzheimer’s pathology on cognitive trajectories in nondemented elderly. Ann Neurol, 60(6), 688–695.

    Article  PubMed  Google Scholar 

  • Dunn, R. T., Kimbrell, T. A., Ketter, T. A., Frye, M. A., Willis, M. W., Luckenbaugh, D. A., et al. (2002). Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression. Biol Psychiatry, 51(5), 387–399.

    Article  CAS  PubMed  Google Scholar 

  • Ernst, C., & Angst, J. (1992). The Zurich Study. XII. Sex differences in depression. Evidence from longitudinal epidemiological data. Eur Arch Psychiatry Clin Neurosci, 241(4), 222–230.

    CAS  Google Scholar 

  • Frodl, T., Koutsouleris, N., Bottlender, R., Born, C., Jager, M., Scupin, I., et al. (2008). Depression-related variation in brain morphology over 3 years: effects of stress? Arch Gen Psychiatry, 65(10), 1156–1165.

    Article  PubMed  Google Scholar 

  • Frodl, T., Meisenzahl, E., Zetzsche, T., Bottlender, R., Born, C., Groll, C., et al. (2002a). Enlargement of the amygdala in patients with a first episode of major depression. Biol Psychiatry, 51(9), 708–714.

    Article  Google Scholar 

  • Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Groll, C., Jager, M., et al. (2002b). Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry, 159(7), 1112–1118.

    Article  Google Scholar 

  • Fuhrer, R., Dufouil, C., & Dartigues, J. F. (2003). Exploring sex differences in the relationship between depressive symptoms and dementia incidence: prospective results from the PAQUID Study. J Am Geriatr Soc, 51(8), 1055–1063.

    Article  PubMed  Google Scholar 

  • Gerton, B. K., Brown, T. T., Meyer-Lindenberg, A., Kohn, P., Holt, J. L., Olsen, R. K., et al. (2004). Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimaging. Neuropsychologia, 42(13), 1781–1787.

    Article  PubMed  Google Scholar 

  • Goldman-Rakic, P. S., & Brown, R. M. (1981). Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neuroscience, 6(2), 177–187.

    Article  CAS  PubMed  Google Scholar 

  • Goldszal, A. F., Davatzikos, C., Pham, D. L., Yan, M. X., Bryan, R. N., & Resnick, S. M. (1998). An image-processing system for qualitative and quantitative volumetric analysis of brain images. J Comput Assist Tomogr, 22(5), 827–837.

    Article  CAS  PubMed  Google Scholar 

  • Greenberg, D. L., Payne, M. E., MacFall, J. R., Steffens, D. C., & Krishnan, R. R. (2008). Hippocampal volumes and depression subtypes. Psychiatry Res, 163(2), 126–132.

    Article  PubMed  Google Scholar 

  • Gualtieri, C. T., & Johnson, L. G. (2008). Age-related cognitive decline in patients with mood disorders. Prog Neuropsychopharmacol Biol Psychiatry, 32(4), 962–967.

    Article  PubMed  Google Scholar 

  • Gueorguieva, R., & Krystal, J. H. (2004). Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry. Arch Gen Psychiatry, 61(3), 310–317.

    Article  PubMed  Google Scholar 

  • Haringsma, R., Engels, G. I., Beekman, A. T., & Spinhoven, P. (2004). The criterion validity of the Center for Epidemiological Studies Depression Scale (CES-D) in a sample of self-referred elders with depressive symptomatology. Int J Geriatr Psychiatry, 19(6), 558–563.

    Article  CAS  PubMed  Google Scholar 

  • Harvey, P. D., Reichenberg, A., & Bowie, C. R. (2006). Cognition and aging in psychopathology: focus on schizophrenia and depression. Annu Rev Clin Psychol, 2, 389–409.

    Article  PubMed  Google Scholar 

  • Herrmann, L. L., Goodwin, G. M., & Ebmeier, K. P. (2007). The cognitive neuropsychology of depression in the elderly. Psychol Med, 37(12), 1693–1702.

    Article  PubMed  Google Scholar 

  • Kawas, C., Gray, S., Brookmeyer, R., Fozard, J., & Zonderman, A. (2000). Age-specific incidence rates of Alzheimer’s disease: the Baltimore Longitudinal Study of Aging. Neurology, 54(11), 2072–2077.

    CAS  PubMed  Google Scholar 

  • Konarski, J. Z., Kennedy, S. H., McIntyre, R. S., Rafi-Tari, S., Soczynska, J. K., & Mayberg, H. S. (2007). Relationship between regional brain metabolism, illness severity and age in depressed subjects. Psychiatry Res, 155(3), 203–210.

    Article  CAS  PubMed  Google Scholar 

  • Kumar, A., Jin, Z., Bilker, W., Udupa, J., & Gottlieb, G. (1998). Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI. Proc Natl Acad Sci U S A, 95(13), 7654–7658.

    Article  CAS  PubMed  Google Scholar 

  • Kumar, A., Schweizer, E., Jin, Z., Miller, D., Bilker, W., Swan, L. L., et al. (1997). Neuroanatomical substrates of late-life minor depression. A quantitative magnetic resonance imaging study. Arch Neurol, 54(5), 613–617.

    CAS  Google Scholar 

  • Lai, T., Payne, M. E., Byrum, C. E., Steffens, D. C., & Krishnan, K. R. (2000). Reduction of orbital frontal cortex volume in geriatric depression. Biol Psychiatry, 48(10), 971–975.

    Article  CAS  PubMed  Google Scholar 

  • Lamar, M., Resnick, S. M., & Zonderman, A. B. (2003). Longitudinal changes in verbal memory in older adults: distinguishing the effects of age from repeat testing. Neurology, 60(1), 82–86.

    PubMed  Google Scholar 

  • Lavretsky, H., Kurbanyan, K., Ballmaier, M., Mintz, J., Toga, A., & Kumar, A. (2004). Sex differences in brain structure in geriatric depression. Am J Geriatr Psychiatry, 12(6), 653–657.

    PubMed  Google Scholar 

  • Lesser, I. M., Boone, K. B., Mehringer, C. M., Wohl, M. A., Miller, B. L., & Berman, N. G. (1996). Cognition and white matter hyperintensities in older depressed patients. Am J Psychiatry, 153(10), 1280–1287.

    CAS  PubMed  Google Scholar 

  • Lockwood, K. A., Alexopoulos, G. S., & van Gorp, W. G. (2002). Executive dysfunction in geriatric depression. Am J Psychiatry, 159(7), 1119–1126.

    Article  PubMed  Google Scholar 

  • MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., et al. (2003). Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci U S A, 100(3), 1387–1392.

    Article  CAS  PubMed  Google Scholar 

  • Mayberg, H. S. (2003). Positron emission tomography imaging in depression: a neural systems perspective. Neuroimaging Clin N Am, 13(4), 805–815.

    Article  PubMed  Google Scholar 

  • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34(7), 939–944.

    CAS  PubMed  Google Scholar 

  • Milak, M. S., Parsey, R. V., Keilp, J., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2005). Neuroanatomic correlates of psychopathologic components of major depressive disorder. Arch Gen Psychiatry, 62(4), 397–408.

    Article  PubMed  Google Scholar 

  • Nutt, D. J., Baldwin, D. S., Clayton, A. H., Elgie, R., Lecrubier, Y., Montejo, A. L., et al. (2006). Consensus statement and research needs: the role of dopamine and norepinephrine in depression and antidepressant treatment. J Clin Psychiatry, 67(Suppl 6), 46–49.

    PubMed  Google Scholar 

  • Ongur, D., Drevets, W. C., & Price, J. L. (1998). Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A, 95(22), 13290–13295.

    Article  CAS  PubMed  Google Scholar 

  • Pantel, J., Schroder, J., Essig, M., Popp, D., Dech, H., Knopp, M. V., et al. (1997). Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia. J Affect Disord, 42(1), 69–83.

    Article  CAS  PubMed  Google Scholar 

  • Panza, F., D’Introno, A., Colacicco, A. M., Capurso, C., Del Parigi, A., & Caselli, R. J. (2009). et al. Temporal Relationship between Depressive Symptoms and Cognitive Impairment: The Italian Longitudinal Study on Aging. J Alzheimers Dis.

    Google Scholar 

  • Park, D., & Minear, M. (2004). Cognitive aging: New directions for old theories. In R. Dixon, L. Backman & L. Nilsson (Eds.), New Frontiers in Cognitive Aging. New York: Oxford University Press.

    Google Scholar 

  • Piccinelli, M., & Wilkinson, G. (2000). Gender differences in depression. Critical review. Br J Psychiatry, 177, 486–492.

    Article  CAS  Google Scholar 

  • Pizzagalli, D. A., Peccoralo, L. A., Davidson, R. J., & Cohen, J. D. (2006). Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG study. Hum Brain Mapp, 27(3), 185–201.

    Article  PubMed  Google Scholar 

  • Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401.

    Article  Google Scholar 

  • Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., et al. (1999). Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry, 45(9), 1085–1098.

    Article  CAS  PubMed  Google Scholar 

  • Rapp, M. A., Dahlman, K., Sano, M., Grossman, H. T., Haroutunian, V., & Gorman, J. M. (2005). Neuropsychological differences between late-onset and recurrent geriatric major depression. Am J Psychiatry, 162(4), 691–698.

    Article  PubMed  Google Scholar 

  • Ravdin, L. D., Katzen, H. L., Agrawal, P., & Relkin, N. R. (2003). Letter and semantic fluency in older adults: effects of mild depressive symptoms and age-stratified normative data. Clin Neuropsychol, 17(2), 195–202.

    CAS  PubMed  Google Scholar 

  • Raz, N. (2004). The aging brain observed in vivo: Differential changes and their modifiers. In R. Cabeza, L. Nyberg & D. Park (Eds.), Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging. New York: Oxford University Press.

    Google Scholar 

  • Reitan, R. (1992). Trail Making Test: Manual for Administration and Scoring. Tucson, AZ: Reitan Neuropsychological Laboratory.

    Google Scholar 

  • Resnick, S. M., Goldszal, A. F., Davatzikos, C., Golski, S., Kraut, M. A., Metter, E. J., et al. (2000). One-year age changes in MRI brain volumes in older adults. Cereb Cortex, 10(5), 464–472.

    Article  CAS  PubMed  Google Scholar 

  • Resnick, S. M., Lamar, M., & Driscoll, I. (2007). Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changes. Ann N Y Acad Sci, 1121, 562–575.

    Article  PubMed  Google Scholar 

  • Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003). Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci, 23(8), 3295–3301.

    CAS  PubMed  Google Scholar 

  • Sachs-Ericsson, N., Joiner, T., Plant, E. A., & Blazer, D. G. (2005). The influence of depression on cognitive decline in community-dwelling elderly persons. Am J Geriatr Psychiatry, 13(5), 402–408.

    PubMed  Google Scholar 

  • Salloway, S., Malloy, P., Kohn, R., Gillard, E., Duffy, J., Rogg, J., et al. (1996). MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology, 46(6), 1567–1574.

    CAS  PubMed  Google Scholar 

  • Shen, D., & Davatzikos, C. (2002). HAMMER: hierarchical attribute matching mechanism for elastic registration. IEEE Trans Med Imaging, 21(11), 1421–1439.

    Article  PubMed  Google Scholar 

  • Shock, N. W., Greulich, R. C., Andres, R., Arenberg, D., Costa, P. T. J., Lakatta, E. G., et al. (1984). Normal human aging: the Baltimore longitudinal study of aging. Washington, DC: U.S. Government Printing Office.

    Google Scholar 

  • Taki, Y., Kinomura, S., Awata, S., Inoue, K., Sato, K., Ito, H., et al. (2005). Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: a voxel-based morphometry. J Affect Disord, 88(3), 313–320.

    Article  PubMed  Google Scholar 

  • Tekin, S., & Cummings, J. L. (2002). Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res, 53(2), 647–654.

    Article  PubMed  Google Scholar 

  • Tucker, D. M., Luu, P., Frishkoff, G., Quiring, J., & Poulsen, C. (2003). Frontolimbic response to negative feedback in clinical depression. J Abnorm Psychol, 112(4), 667–678.

    Article  PubMed  Google Scholar 

  • Videbech, P., Ravnkilde, B., Pedersen, T. H., Hartvig, H., Egander, A., Clemmensen, K., et al. (2002). The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatr Scand, 106(1), 35–44.

    CAS  Google Scholar 

  • Wechsler, D. (1981). Wechsler Adult Intelligence Scale—Revised. New York: The Psychological Corporation.

    Google Scholar 

  • Wilson, R. S., Mendes De Leon, C. F., Bennett, D. A., Bienias, J. L., & Evans, D. A. (2004). Depressive symptoms and cognitive decline in a community population of older persons. J Neurol Neurosurg Psychiatry, 75(1), 126–129.

    CAS  PubMed  Google Scholar 

  • Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., et al. (1983). Development and validation of a Geriatric Depression Screening Scale: A preliminary report. Journal of Psychiatric Research, 17(1), 37–49.

    Article  CAS  Google Scholar 

  • Yuan, Y., Zhang, Z., Bai, F., Yu, H., Shi, Y., Qian, Y., et al. (2008). Abnormal neural activity in the patients with remitted geriatric depression: A resting-state functional magnetic resonance imaging study. J Affect Disord, 111(2–3), 145–152.

    Article  PubMed  Google Scholar 

  • Yuan, Y., Zhang, Z., Bai, F., Yu, H., Shi, Y., Qian, Y., et al. (2007). White matter integrity of the whole brain is disrupted in first-episode remitted geriatric depression. Neuroreport, 18(17), 1845–1849.

    Article  PubMed  Google Scholar 

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Acknowledgment

This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging.

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  1. Vonetta M. Dotson

    Present address: Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA

Authors and Affiliations

  1. Department of Clinical and Health Psychology, University of Florida, P.O. Box 100165, Gainesville, FL, 32610-0165, USA

    Vonetta M. Dotson

  2. Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room #4B316, Baltimore, MD, 21224, USA

    Alan B. Zonderman & Susan M. Resnick

  3. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    Christos Davatzikos

  4. Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Michael A. Kraut

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Dotson, V.M., Zonderman, A.B., Davatzikos, C. et al. Frontal Atrophy and Attention Deficits in Older Adults with a History of Elevated Depressive Symptoms. Brain Imaging and Behavior 3, 358–369 (2009). https://doi.org/10.1007/s11682-009-9078-z

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