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Altered regional homogeneity in pediatric bipolar disorder during manic and euthymic state: a resting-state fMRI study

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Abstract

Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. Regional homogeneity (ReHo) was examined with resting-state fMRI on 22 manic PBD patients, 21 euthymic PBD patients and 19 healthy controls. Compared with control group, manic group presented reduced cortical ReHo signal in the superior temporal gyrus(STG), the superior parietal lobe (SPL), precentral gyrus and altered subcortical ReHo signal in the insula and cerebelum crus I. Compared with control group, euthymic group only presented reduced cortical ReHo signal in the STG and SPL. Compared with euthymic group, we found reduced ReHo signal in insula, the STG and increased ReHo signal in cerebelum crus I in the manic group. The neural regions we found to have altered ReHo signal in the PBD manic and euthymic group are parts of the cortical-limbic systems, which are important for affective and cognitive processing. Importantly, our findings suggested that there was a difference between manic and euthymic PBD in the insula, cerebelum crus I and the STG.

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Funding

This study was funded by Natural Science Foundation of Hunan Province: No. 2018JJ3832, National Natural Science Foundation of China (81371531,81171291, 81201077), the Natural Science Foundation of Jiangsu Province (BK20161109).

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Authors and Affiliations

  1. Mental Health Centre of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

    Qian Xiao

  2. Department of Radiology, Taishan Medical University, Taian, 271016, China

    Dong Cui, Qing Jiao & Weifang Cao

  3. Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China

    Yuan Zhong & Guangming Lu

  4. School of Psychology, Nanjing Normal University, Nanjing, 210097, China

    Yuan Zhong

  5. Department of Psychiatry, Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, 410011, Hunan, China

    Linyan Su

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Correspondence to Guangming Lu or Linyan Su.

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No conflict exists: Author Qian Xiao declares that she has no conflict of interest. Author Dong Cui declares that he has no conflict of interest. Author Qing Jiao declares that she has no conflict of interest. Author Yuan Zhong declares that he has no conflict of interest. Author Guangming Lu declares that he has no conflict of interest. Author Linyan Su declares that she has no conflict of interest.

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Xiao, Q., Cui, D., Jiao, Q. et al. Altered regional homogeneity in pediatric bipolar disorder during manic and euthymic state: a resting-state fMRI study. Brain Imaging and Behavior 13, 1789–1798 (2019). https://doi.org/10.1007/s11682-019-00117-4

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