Abstract
Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating pattern of depressive and manic episodes with a separated period of euthymia. It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in pediatric BD (PBD) patients.Resting-state fMRI signals of sixteen euthymic PBD patients and 16 healthy controls were processed and FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) and functional connectivity were calculated in the present study. Voxel-wised correlation between clinical and cognitive indices and FOCA in PBD was calculated.Compared with healthy subjects, euthymic PBD patients showed worse performance in tests of Stroop Color-Word Test, Digit Span Test and Trail Making Test. Euthymic PBD patients demonstrated increased FOCA in left inferior frontal gyrus, left anterior cingulate cortex and left superior frontal gyrus and decreased FOCA in right orbital frontal gyrus, bilateral precuneus, right superior occipital gyrus and bilateral superior parietal gyrus. Decreased functional connectivities were found between right orbital frontal gyrus and left amygdala, between left superior frontal gyrus and left putamen, and between left superior frontal gyrus and left insula. And increased functional connectivity was found between right superior occipital gyrus and right hippocampus. FOCA of parahippocampal gyrus was negatively correlated with the SCWT-B score in PBD patients.Abnormal spatiotemporal consistency of brain regions of corticolimbic circuitry is possible to contribute to an imbalance between emotional processing and cognitive control in euthymic PBD. The measurement of FOCA measure may provide important clues of understanding PBD.
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Funding
The present work was supported by the Funds for the National Natural Science Foundation of China (81371531to Qing Jiao; 81901730to Weifang Cao), Science and Technology Project of the Education Department of Shandong Province (J18KA262 to Weifang Cao), High-level cultivation program of Shandong First Medical University &Shandong Academy of Medical Sciences (2017GCC11 to Weifang Cao), and Taishan Scholars Program of Shandong Province (TS201712065 to Jianfeng Qiu), Key Project of Scientific Research of “12th Five-Year Plan” in Medical Research of the Army (BWS11J063 to Guangming Lu).
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Author contributions included conception and study design (Qing Jiao and Guangming Lu), data collection or acquisition and clinical support (Weijia Gao and Linyan Su), statistical analysis (Dong Cui and Jinfeng Wang), interpretation of results(Yongxin Guo and Jianfeng Qiu), drafting the manuscript work or revising it critically for important intellectual content (Yongxin Guo and Jinfeng Wang) and approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (All authors).
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Guo, Y., Wang, J., Jiao, Q. et al. Altered spatiotemporal consistency of corticolimbic circuitry in euthymic pediatric bipolar disorder. Brain Imaging and Behavior 15, 1290–1299 (2021). https://doi.org/10.1007/s11682-020-00327-1
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DOI: https://doi.org/10.1007/s11682-020-00327-1