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Reduction in Plasma Levels of Inflammatory and Oxidative Stress Indicators After Roux-En-Y Gastric Bypass

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Abstract

Background

Obesity is considered to be associated with high levels of oxidative stress and inflammation. Anticipated weight loss secondary to bariatric surgery may offer an opportunity to evaluate this association. We studied a few markers of oxidative stress and inflammation in 20 obese patients submitted to Roux-en-Y gastric bypass (RYGBP).

Methods

Variations in plasma levels of indicators of oxidative stress (malondialdehyde (MDA), superoxide dismutase (SOD), catalase, glutathione (GSH), glutathione disulfide (GSSG), and total radical antioxidant parameter (TRAP)) and inflammation (α1-acid glycoprotein (AGP) and C-reactive protein (CRP)), as well as variations in plasma levels of leptin, glucose, glycated hemoglobin (HbA1c), and insulin were investigated in the preoperative period and 12 months postsurgery in 20 class III obese individuals submitted to bariatric surgery (obese group) and 20 non-obese individuals (control group).

Results

Twelve months postsurgery, there was a significant reduction (p < 0.01) in median values of BMI (46.75/30.17 kg/m2) and in plasma levels of MDA (16.70/9.11 nmol/g prot), SOD (10.70/9.24 U/mgHb), GSSG (210.80/148.20 mM/g of Hb), AGP (125.70/75.80 mg/dL), CRP (1.31/0.38 mg/dL), and leptin (15.04/3.58 ng/mL). A significant drop (p < 0.05) in plasma levels of HbA1c (5.81/4.98%) was also observed. On the other hand, a significant increase in plasma levels of GSH (2.002/2.823 mM/g of Hb) and TRAP (585.40/815.48 μM Trolox®), p < 0.01, and in catalase plasma levels (12.06/13.22 Δt/mgHb/min), p < 0.05, was seen. No statistically significant variations in glucose (96.3/84.8 mg/dL) or insulin plasma levels (9.91/7.88 U/mL) occurred. Calculated homeostasis model assessment index did not statistically change 12 months postsurgery (2.36/1.66).

Conclusions

In the preoperative period, the obese group individuals showed higher oxidation and inflammation levels and lower indices of antioxidant defense than those of the control group. One year after RYGBP, an improvement in antioxidant protection, associated with a reduction in inflammatory and oxidative markers, was observed, indicating that these individuals presented a lower degree of oxidative stress.

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Authors and Affiliations

  1. Pharmaceutical University Hospital, University Hospital, Londrina State University, Londrina, Brazil

    Edilson João Cabrera

  2. Department of Surgery, University Hospital, Londrina State University, Londrina, Brazil

    Antonio Carlos Valezi

  3. Department of Internal Medicine, University Hospital, Londrina State University, Londrina, Brazil

    Vinicius Daher Alvares Delfino

  4. Department of Physiotherapy, University Hospital, Londrina State University, Londrina, Brazil

    Edson Lopes Lavado

  5. Department of Pathology, Clinical Analysis and Toxicology, University Hospital, Londrina State University, Av. Robert Koch, 60, 86038-350, Londrina, Paraná, Brazil

    Decio Sabbatini Barbosa

Authors
  1. Edilson João Cabrera
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  2. Antonio Carlos Valezi
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  3. Vinicius Daher Alvares Delfino
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  4. Edson Lopes Lavado
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  5. Decio Sabbatini Barbosa
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Correspondence to Decio Sabbatini Barbosa.

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João Cabrera, E., Valezi, A.C., Delfino, V.D.A. et al. Reduction in Plasma Levels of Inflammatory and Oxidative Stress Indicators After Roux-En-Y Gastric Bypass. OBES SURG 20, 42–49 (2010). https://doi.org/10.1007/s11695-009-9988-2

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