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Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery

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Abstract

Background

This study examined the effect of weight loss on energy intake, vitamin C, E, β-carotene (diet/blood), reduced glutathione (GSH), C-reactive protein (CRP), thiobarbituric acid reactive substances (TBARS), catalase, and myeloperoxidase, in patients with Roux-en-Y bypass gastroplasty.

Methods

Prospective clinical study with control (C) and bariatric (B) groups (n = 20 each). Age was 38.8 ± 11.1 (C) and 37.8 ± 11.2 years (B), and body mass indices (BMI) were 22.4 ± 2.4 and 48.1 ± 8.7 kg/m2, respectively. Group C was assessed on a single occasion and B at three time points (basal period and 3 and 6 months after gastroplasty).

Results

BMI was decreased at three (38.3 ± 1.7, P = 0.018) and 6 months after surgery (34.9 ± 1.7, P < 0.001). Mean weight loss was 20.53 ± 1.1 after three and 27.96 ± 1.3 kg after 6 months. Serum vitamin C and β-carotene (P < 0.01 and P < 0.001, respectively) were increased at 6 months compared to basal. Basal serum vitamin C (P = 0.001) and β-carotene (P < 0.001) were lower compared to controls. Serum vitamin E corrected for cholesterol and triglycerides was higher in group B at three (P = 0.01) and 6 months (P = 0.001) and lower at basal (P < 0.001) compared to controls. GSH was higher in controls (P < 0.001) compared to basal. Catalase (P = 0.01) and TBARS (P < 0.001) were higher in group B at 6 months. TBARS were higher (P < 0.001) at basal compared to controls. Myeloperoxidase and CRP decreased in group B after three (P = 0.028, P = 0.010) and 6 months (P < 0.001, P = 0.001), respectively.

Conclusions

Roux-en-Y bypass gastroplasty led to decreased proinflammatory parameters together with increased nutritional antioxidants, catalase, and TBARS, and decreased GSH 6 months after surgery.

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Acknowledgments

The authors are grateful to the following for financial support: Fundação de Apoio à Pesquisa Científica e Tecnológica do Estado de Santa Catarina (FAPESC): Grant no. CON 14191/2007-7; Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq, Programa Institucional de Bolsa de Iniciação Científica - Conselho Nacional de Desenvolvimento Científico e Tecnológico, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES. Statement of authorships: Moreira, Fröde, Wilhelm Filho had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Moreira, Fröde, Wilhelm Filho. Acquisition of data: Boesing. Analysis and interpretation of data: Vigil, Parizotto, Inácio, Portinari, Trindade, Jordão Júnior. Drafting of the manuscript: Moreira, Fröde, Wilhelm Filho. Critical revision of the manuscript for important intellectual content: Moreira, Fröde, Wilhelm Filho. Statistical analysis: Boesing, Moreira. Final approval of the version to be submitted: Moreira, Fröde, Wilhelm Filho. Obtained funding: Moreira, Trindade.

Conflict of Interest Statement

No conflict of interest needs to be reported; the funding agency had no role in the analysis or interpretation of the data or in the decision to submit the report for publication.

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Authors and Affiliations

  1. Post-Graduate Program in Nutrition, Universidade Federal de Santa Catarina, Florianópolis, Brazil

    Fernanda Boesing

  2. Department of Nutrition and Post-Graduate Program in Nutrition, Universidade Federal de Santa Catarina, Florianópolis, Brazil

    Emilia Addison Machado Moreira & Erasmo Benício Santos Moraes Trindade

  3. Department of Ecology and Zoology, Universidade Federal de Santa Catarina, Florianópolis, Brazil

    Danilo Wilhelm-Filho

  4. Post-Graduate Program in Pharmacy, Universidade Federal de Santa Catarina, Florianópolis, Brazil

    Silvana Virgínia Gagliotti Vigil

  5. Graduate Program in Pharmacy, Universidade Federal de Santa Catarina, Florianópolis, Brazil

    Eduardo Bennedetti Parizottto & Déborah Bunn Inácio

  6. Department of Internal Medicine at the Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

    Guilherme Vannucchi Portari & Alceu Afonso Jordão-Júnior

  7. Department of Clinical Analysis, Universidade Federal de Santa Catarina, Florianópolis, Brazil

    Tânia Silvia Fröde

  8. Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Campus Universitário, CEP: 88040-970, Florianópolis, Santa Catarina, Brazil

    Emilia Addison Machado Moreira

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  1. Fernanda Boesing
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Correspondence to Emilia Addison Machado Moreira.

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Boesing, F., Moreira, E.A.M., Wilhelm-Filho, D. et al. Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery. OBES SURG 20, 1236–1244 (2010). https://doi.org/10.1007/s11695-010-0196-x

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