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Self-reported global function among adult survivors of childhood lower-extremity bone tumors: a report from the Childhood Cancer Survivor Study (CCSS)

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Abstract

Introduction

Adult survivors of childhood lower-extremity bone tumors may experience physical and psychosocial late effects that impact physical performance, global function and quality of life. The identification of survivors at greatest risk for poor outcomes will inform potential intervention targets.

Methods

Study participants were selected from the Childhood Cancer Survivor Study (CCSS), a multi-institutional study of childhood cancer survivors. Adult survivors (n = 629) of either childhood onset osteosarcoma or Ewing’s sarcoma, with a primary tumor location in the lower-extremity were identified and contacted via mail to complete an additional questionnaire. Participants completed the Reintegration into Normal Living Index (RNL) to evaluate global function (maximum score of 22), daily function (maximum score of 16) and self perception (maximum score of 6).

Results

Survivors reported high levels of global function with an adjusted mean overall RNL index score of 20.6 (SE 0.14), mean daily function score of 15.0 (SD 0.10) and mean self perception score of 5.6 (SE 0.05). While female gender and increasing age were associated with lower RNL scores, the magnitude of difference is of questionable clinical significance. Global function was only moderately correlated with physical performance (r = 0.56) and QOL (r = 0.59).

Discussion

Based upon the RNL index, the vast majority of long-term survivors of childhood lower extremity bone tumors adapt well to their environment.

Implications for cancer survivors

While some long-term survivors of lower-extremity bone tumors may report measurable limitations in physical performance and quality of life, the majority do not report moderate or severe difficulties with social integration.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC R7015, Cincinnati, OH, 45229, USA

    Rajaram Nagarajan

  2. Division of Hematology-Oncology and Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota, 420 Delaware St SE, Minneapolis, MN, 55455, USA

    Joesph P. Neglia

  3. Department of Epidemiology and Cancer Control, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA

    Rona Mogil, Leslie L. Robison & Kirsten K. Ness

Authors
  1. Rajaram Nagarajan
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  2. Rona Mogil
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  3. Joesph P. Neglia
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  4. Leslie L. Robison
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  5. Kirsten K. Ness
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Corresponding author

Correspondence to Rajaram Nagarajan.

Additional information

This work was supported by grant CA 55727 (LL Robison, Principal Investigator), National Cancer Institute, Bethesda, MD, with additional support provided to St. Jude Children’s Research Hospital by the American Lebanese Syrian Associated Charities (ALSAC), to the University of Minnesota by the Children’s Cancer Research Fund and to R Nagarajan by the National Childhood Cancer Foundation, Arcadia, CA (Research Fellowship) and the American Society of Clinical Oncology, Alexandria, VA (Young Investigator Award)

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Nagarajan, R., Mogil, R., Neglia, J.P. et al. Self-reported global function among adult survivors of childhood lower-extremity bone tumors: a report from the Childhood Cancer Survivor Study (CCSS). J Cancer Surviv 3, 59–65 (2009). https://doi.org/10.1007/s11764-008-0073-y

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  • DOI: https://doi.org/10.1007/s11764-008-0073-y

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