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Osteoporosis and Orthopedic Surgery: Effect of Bone Health on Total Joint Arthroplasty Outcome

  • SURGERY AND PERIOPERATIVE CARE (CR MACKENZIE AND SM GOODMAN, SECTION EDITORS)
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Abstract

Osteoporosis is a common condition. As the population ages, more patients with osteoporosis will require orthopedic procedures, including arthroplasty. Adverse outcomes are more likely for patients with osteoporosis requiring orthopedic procedures, for example those with intraoperative fractures, periprosthetic osteolysis with implant migration, and postoperative periprosthetic fractures. Cemented prosthetic hip replacements may be more successful among patients with poor bone quality. Femoral neck fracture is a concern during hip resurfacing among patients with osteoporosis. Vitamin D deficiency is common among patients undergoing joint arthroplasty and the ideal vitamin D level for joint arthroplasty has yet to be determined. Both bisphosphonates and teriparatide may aide successful osteointegration among patients undergoing noncemented joint arthroplasty. Focusing on bone health perioperatively should result in better outcomes for orthopedic procedures.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Nicodemus KK, Folsom AR, Anderson KE. Menstrual history and risk of hip fractures in postmenopausal women. the Iowa women's health study. Am J Epidemiol. 2001;153(3):251–5.

    Article  PubMed  CAS  Google Scholar 

  2. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the united states from 2005 to 2030. J Bone Joint Surg Am. 2007;89(4):780–5.

    Article  PubMed  Google Scholar 

  3. • Lingard EA, Mitchell SY, Francis RM, et al. The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty. Age Ageing. 2010;39(2):234–9. Discusses the prevalence of osteoporosis among patients with severe hip and knee osteoarthritis awaiting joint arthroplasty..

    Article  PubMed  Google Scholar 

  4. Makinen TJ, Alm JJ, Laine H, Svedstrom E, Aro HT. The incidence of osteopenia and osteoporosis in women with hip osteoarthritis scheduled for cementless total joint replacement. Bone. 2007;40(4):1041–7.

    Article  PubMed  Google Scholar 

  5. Urban RM, Hall DJ, Della Valle C, Wimmer MA, Jacobs JJ, Galante JO. Successful long-term fixation and progression of osteolysis associated with first-generation cementless acetabular components retrieved post mortem. J Bone Joint Surg Am. 2012;94(20):1877–85.

    Article  PubMed  Google Scholar 

  6. Moritz N, Alm JJ, Lankinen P, Makinen TJ, Mattila K, Aro HT. Quality of intertrochanteric cancellous bone as predictor of femoral stem RSA migration in cementless total hip arthroplasty. J Biomech. 2011;44(2):221–7.

    Article  PubMed  Google Scholar 

  7. Yli-Kyyny T, Ojanpera J, Venesmaa P, et al. Perioperative complications after cemented or uncemented hemiarthroplasty in hip fracture patients. Scand J Surg. 2013;102(2):124–8.

    Article  PubMed  CAS  Google Scholar 

  8. Popescu D, Ene R, Cirstoiu C. Resurfacing total hip replacement—a therapeutical approach in postmenopausal women with osteoporosis and hip arthrosis. J Med Life. 2011;4(2):178–81.

    PubMed  CAS  Google Scholar 

  9. Marsland D, Mears SC. A review of periprosthetic femoral fractures associated with total hip arthroplasty. Geriatr Orthop Surg Rehabil. 2012;3(3):107–20.

    Article  PubMed  Google Scholar 

  10. Cross MB, Nam D, van der Meulen MC, Bostrom MP. A rare case of a bisphosphonate-induced peri-prosthetic femoral fracture. J Bone Joint Surg Br. 2012;94(7):994–7.

    PubMed  CAS  Google Scholar 

  11. Kamath S, Chang W, Shaari E, Bridges A, Campbell A, McGill P. Comparison of peri-prosthetic bone density in cemented and uncemented total knee arthroplasty. Acta Orthop Belg. 2008;74(3):354–9.

    PubMed  Google Scholar 

  12. Kim K, Kim YH, Park WM, Rhyu KH. Stress concentration near pin holes associated with fracture risk after computer navigated total knee arthroplasty. Comput Aided Surg. 2010;15(4–6):98–103.

    Article  PubMed  CAS  Google Scholar 

  13. • Lee DH, Padhy D, Lee SH, Nha KW, Park JH, Han SB. Osteoporosis affects component positioning in computer navigation-assisted total knee arthroplasty. Knee. 2012;19(3):203–7.

    Article  PubMed  Google Scholar 

  14. Wiley KF, Ding K, Stoner JA, Teague DC, Yousuf KM. Incidence of pseudotumor and acute lymphocytic vasculitis associated lesion (ALVAL) reactions in metal-on-metal hip articulations: A meta-analysis. J Arthroplasty. 2013.

  15. •• Nawabi DH, Hayter CL, Su EP, et al. Magnetic resonance imaging findings in symptomatic versus asymptomatic subjects following metal-on-metal hip resurfacing arthroplasty. J Bone Joint Surg Am. 2013;95(10):895–902. Describes MRI findings in metal-on-metal hip arthroplasty..

    Article  PubMed  Google Scholar 

  16. Lingen CV, Ettema H, Timmer J, Jong GD, Verheyen C. Clinical manifestations in ten patients with asymptomatic metal-on-metal hip arthroplasty with very high cobalt levels. Hip Int. 2013:0.

  17. Hasegawa M, Yoshida K, Wakabayashi H, Sudo A. Prevalence of adverse reactions to metal debris following metal-on-metal THA. Orthopedics. 2013;36(5):e606–12.

    Article  PubMed  Google Scholar 

  18. Rosen CJ, Gallagher JC. The 2011 IOM report on vitamin D and calcium requirements for North America: Clinical implications for providers treating patients with low bone mineral density. J Clin Densitom. 2011;14(2):79–84.

    Article  PubMed  Google Scholar 

  19. • Bogunovic L, Kim AD, Beamer BS, Nguyen J, Lane JM. Hypovitaminosis D in patients scheduled to undergo orthopaedic surgery: A single-center analysis. J Bone Joint Surg Am. 2010;92(13):2300–4. Describes degree of vitamin D deficiency in patients undergoing orthopedic surgery..

    Article  PubMed  Google Scholar 

  20. Breijawi N, Eckardt A, Pitton MB, et al. Bone mineral density and vitamin D status in female and male patients with osteoarthritis of the knee or hip. Eur Surg Res. 2009;42(1):1–10.

    Article  PubMed  CAS  Google Scholar 

  21. Bergink AP, Uitterlinden AG, Van Leeuwen JP, et al. Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: The Rotterdam study. J Clin Rheumatol. 2009;15(5):230–7.

    Article  PubMed  Google Scholar 

  22. • Unnanuntana A, Rebolledo BJ, Gladnick BP, et al. Does vitamin D status affect the attainment of in-hospital functional milestones after total hip arthroplasty? J Arthroplasty. 2012;27(3):482–9. Describes vitamin D status and the effect on in-house functional milestones after hip arthroplasty..

    Article  PubMed  Google Scholar 

  23. Diamond T, Wong YK, Golombick T. Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporos Int. 2012.

  24. Mastaglia SR, Seijo M, Muzio D, Somoza J, Nunez M, Oliveri B. Effect of vitamin D nutritional status on muscle function and strength in healthy women aged over sixty-five years. J Nutr Health Aging. 2011;15(5):349–54.

    Article  PubMed  CAS  Google Scholar 

  25. Muir SW, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: A systematic review and meta-analysis. J Am Geriatr Soc. 2011;59(12):2291–300.

    Article  PubMed  Google Scholar 

  26. Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL. Effects of three monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility and muscle strength in older postmenopausal women: A randomised controlled trial. J Bone Miner Res. 2011.

  27. Jakobsen T, Baas J, Bechtold JE, Elmengaard B, Soballe K. Soaking morselized allograft in bisphosphonate can impair implant fixation. Clin Orthop Relat Res. 2007;463:195–201.

    PubMed  Google Scholar 

  28. Muratore M, Quarta E, Quarta L, et al. Ibandronate and cementless total hip arthroplasty: Densitometric measurement of periprosthetic bone mass and new therapeutic approach to the prevention of aseptic loosening. Clin Cases Miner Bone Metab. 2012;9(1):50–5.

    PubMed  Google Scholar 

  29. • Thillemann TM, Pedersen AB, Mehnert F, Johnsen SP, Soballe K. Postoperative use of bisphosphonates and risk of revision after primary total hip arthroplasty: A nationwide population-based study. Bone. 2010;46(4):946–51. Describes the effect of bisphosphonate on implant survival..

    Article  PubMed  CAS  Google Scholar 

  30. Prieto-Alhambra D, Javaid MK, Judge A, et al. Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: Population based retrospective cohort study. BMJ. 2011;343:d7222.

    Article  PubMed  Google Scholar 

  31. Wang CJ, Wang JW, Ko JY, Weng LH, Huang CC. Three-year changes in bone mineral density around the knee after a six-month course of oral alendronate following total knee arthroplasty. A prospective, randomized study. J Bone Joint Surg Am. 2006;88(2):267–72.

    Article  PubMed  Google Scholar 

  32. Prieto-Alhambra D, Javaid MK, Judge A, et al. Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: A propensity score analysis. Osteoporos Int. 2011;22(5):1555–71.

    Article  PubMed  CAS  Google Scholar 

  33. Hansson U, Toksvig-Larsen S, Ryd L, Aspenberg P. Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study. Acta Orthop. 2009;80(1):41–5.

    Article  PubMed  Google Scholar 

  34. Prieto-Alhambra D, Javaid MK, Judge A, et al. Fracture risk before and after total hip replacement in patients with osteoarthritis: Potential benefits of bisphosphonate use. Arthritis Rheum. 2011;63(4):992–1001.

    Article  PubMed  CAS  Google Scholar 

  35. Friedl G, Turner RT, Evans GL, Dobnig H. Intermittent parathyroid hormone (PTH) treatment and age-dependent effects on rat cancellous bone and mineral metabolism. J Orthop Res. 2007;25(11):1454–64.

    Article  PubMed  CAS  Google Scholar 

  36. Daugaard H. The influence of parathyroid hormone treatment on implant fixation. Dan Med Bull. 2011;58(9):B4317.

    PubMed  Google Scholar 

  37. • Oteo-Alvaro A, Matas JA, Alonso-Farto JC. Teriparatide (rh [1–34] PTH) improved osteointegration of a hemiarthroplasty with signs of aseptic loosening. Orthopedics. 2011;34(9):e574–7. Teriparatide leads to better osteointegration in hip arthroplasty..

    PubMed  Google Scholar 

  38. Zati A, Sarti D, Malaguti MC, Pratelli L. Teriparatide in the treatment of a loose hip prosthesis. J Rheumatol. 2011;38(4):778–80.

    Article  PubMed  Google Scholar 

  39. Vasileiadis GI, Sakellariou VI, Kelekis A, et al. Prevention of heterotopic ossification in cases of hypertrophic osteoarthritis submitted to total hip arthroplasty. etidronate or indomethacin? J Musculoskelet Neuronal Interact. 2010;10(2):159–65.

    PubMed  CAS  Google Scholar 

  40. Schuetz P, Mueller B, Christ-Crain M, Dick W, Haas H. Amino-bisphosphonates in heterotopic ossification: First experience in five consecutive cases. Spinal Cord. 2005;43(10):604–10.

    Article  PubMed  CAS  Google Scholar 

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Linda A. Russell declares that she has no conflict of interest.

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Correspondence to Linda A. Russell.

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This article is part of the Topical Collection on Surgery and Perioperative Care

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Russell, L.A. Osteoporosis and Orthopedic Surgery: Effect of Bone Health on Total Joint Arthroplasty Outcome. Curr Rheumatol Rep 15, 371 (2013). https://doi.org/10.1007/s11926-013-0371-x

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  • DOI: https://doi.org/10.1007/s11926-013-0371-x

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