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Selenium Levels in First-Degree Relatives of Diabetic Patients

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Abstract

The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 µg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9 vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 µU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 µmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = − 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = −0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 µg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels ≥ 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 µmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.

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Authors and Affiliations

  1. Department of Endocrinology, Faculty of Medicine, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey

    Mesut Ozkaya & Kadir Gisi

  2. Department of Endocrinology and Metabolism, Gaziantep State Hospital, Gaziantep, Turkey

    Mustafa Sahin

  3. Department of Endocrinology and Metabolism, Yuksek Ihtisas Hospital, Ankara, Turkey

    Erman Cakal

  4. Department of Biochemistry, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey

    Fidan Bilge & Metin Kilinc

  5. Endocrinology and Metabolism Department, Gulhane University School of Medicine, Zulfikar sok 28/8 Buyukesat, Ankara, Turkey

    Mustafa Sahin

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  1. Mesut Ozkaya
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  2. Mustafa Sahin
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  3. Erman Cakal
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  4. Kadir Gisi
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  5. Fidan Bilge
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Correspondence to Mustafa Sahin.

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Ozkaya, M., Sahin, M., Cakal, E. et al. Selenium Levels in First-Degree Relatives of Diabetic Patients. Biol Trace Elem Res 128, 144–151 (2009). https://doi.org/10.1007/s12011-008-8263-z

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  • DOI: https://doi.org/10.1007/s12011-008-8263-z

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