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Protective Effect of Naringenin Against Lead-Induced Oxidative Stress in Rats

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Abstract

Oxidative stress is thought to be involved in lead-induced toxicity. The aim of this study was to investigate the possible protective role of naringenin on lead-induced oxidative stress in the liver and kidney of rats. In the present investigation, lead acetate (500 mg Pb/L) was administered orally for 8 weeks to induce hepatotoxicity and nephrotoxicity. The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, urea, uric acid, and creatinine were significantly (P < 0.05) increased following lead acetate administration. Lead-induced oxidative stress in liver and kidney tissue was indicated by a significant (P < 0.05) increase in the level of maleic dialdehyde and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. Naringenin markedly attenuated lead-induced biochemical alterations in serum, liver, and kidney tissues (P < 0.05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats.

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Acknowledgments

This study was supported by the Research Fund for Doctor of Henan University of Science and Technology (09001489).

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Authors and Affiliations

  1. College of Animal Science and Technology, Henan University of Science and Technology, No.70, Tianjin Road, 471003, Luoyang, People’s Republic of China

    Jicang Wang, Zijun Yang, Lin Lin & Zhanqin Zhao

  2. College of Veterinary Medicine, Yangzhou University, No.12, East Wenhui Road, 225009, Yangzhou, People’s Republic of China

    Zongping Liu & Xuezhong Liu

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  1. Jicang Wang
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  2. Zijun Yang
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  3. Lin Lin
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Correspondence to Xuezhong Liu.

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Wang, J., Yang, Z., Lin, L. et al. Protective Effect of Naringenin Against Lead-Induced Oxidative Stress in Rats. Biol Trace Elem Res 146, 354–359 (2012). https://doi.org/10.1007/s12011-011-9268-6

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  • DOI: https://doi.org/10.1007/s12011-011-9268-6

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